Syndecans-2 and -4; close cousins, but not identical twins.
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Syndecans-2 and -4; close cousins, but not identical twins. / Oh, Eok-Soo; Couchman, John R.
In: Molecules and Cells, Vol. 17, No. 2, 2004, p. 181-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Syndecans-2 and -4; close cousins, but not identical twins.
AU - Oh, Eok-Soo
AU - Couchman, John R
N1 - Keywords: Animals; Cell Adhesion; Cell Division; Cytoskeleton; Growth Substances; Humans; Membrane Glycoproteins; Neovascularization, Physiologic; Protein Conformation; Proteoglycans; Syndecan-2; Syndecan-4; Tissue Distribution
PY - 2004
Y1 - 2004
N2 - The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.
AB - The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.
M3 - Journal article
C2 - 15179029
VL - 17
SP - 181
EP - 187
JO - Molecules and Cells
JF - Molecules and Cells
SN - 1016-8478
IS - 2
ER -
ID: 5160964