Survival of patients with congenital ventricular septal defect
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Aims The long-term survival of patients with isolated congenital ventricular septal defect (VSD) is not well described. The aim of this study was to describe the survival of a national cohort of patients with VSD compared with the general population. Methods Using Danish nationwide medical registries, all patients diagnosed with congenital VSD (n = 9,136) in the period 1977–2018 and results were included. Patients with chromosomal abnormalities and concomitant congenital cardiac malformations other than atrial septal defect were excluded. Each patient was matched by birthyear and sex with ten controls from the general Danish population. Kaplan−Meier survival function and Cox proportional hazard regression were used to compute survival and mortality risk. Median follow-up was 22 years (interquartile range: 11–37). VSD patients displayed lower survival (P<0.001) yielding a hazard ratio (HR) for mortality of 2.7 [95% confidence interval (CI): 2.4–3.0] compared with matched controls. The adjusted HR for mortality among patients with unrepaired VSD was 2.7 (95% CI: 2.4–3.0) and 2.8 (95% CI: 2.1–3.7) for patients with surgically closed VSD. Stratified by era of VSD diagnosis, the HR for mortality was 3.2 (95% CI: 2.8–3.7) for unrepaired patients diagnosed before 1990 and 2.4 (95% CI: 2.0–2.7) for patients diagnosed later. Cardiac-related death was the commonest cause of death among unrepaired (30%) and surgically closed (65%) patients. Conclusion Patients with VSD had lower survival compared with the general population. The HR for mortality was increased over 2.5-fold in patients with unrepaired defect (Eisenmenger syndrome excluded) and over 1.5-fold in patients with surgically closed defect (excluding surgical mortality).
Original language | English |
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Journal | European Heart Journal |
Volume | 44 |
Issue number | 1 |
Pages (from-to) | 54-61 |
Number of pages | 8 |
ISSN | 0195-668X |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
- Congenital heart disease, Long-term outcome, Survival, Ventricular septal defect
Research areas
ID: 343218893