Substrate utilization in the brain and skeletal muscle during environmental and energetic stress in humans
Research output: Book/Report › Ph.D. thesis › Research
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Substrate utilization in the brain and skeletal muscle during environmental and energetic stress in humans. / Caldwell, Hannah Grace.
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2023. 250 p.Research output: Book/Report › Ph.D. thesis › Research
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TY - BOOK
T1 - Substrate utilization in the brain and skeletal muscle during environmental and energetic stress in humans
AU - Caldwell, Hannah Grace
PY - 2023
Y1 - 2023
N2 - Metabolism describes the sum of biochemical reactions that take place within a living organism which provide energy for vital processes; this can be studied at the whole-body, organ specific, or cellular level. Energy availability, which is determined by the difference between energy intake and exercise energy expenditure, is affected by selected environmental and energetic stresses (e.g., high-altitude, exercise, diet/nutrition). Systemic energy deficits have implications for the regulation of organ-specific metabolism. This thesis provides novel insights for integrative brain, skeletal muscle, and systemic substrate oxidation and relative fuel utilization in the context of environmental and energetic stress (e.g., high-altitude, exercise, nutritional caloric deficits). Experiments included: metabolism in the brain in response to CO2; the brain’s inflammatory response to maximal exercise following 6-8 days of acclimatization at 3,800 m; and a diet intervention in females involving 14-days of effectively 50% caloric restriction while maintaining 8 hours of endurance training per week.
AB - Metabolism describes the sum of biochemical reactions that take place within a living organism which provide energy for vital processes; this can be studied at the whole-body, organ specific, or cellular level. Energy availability, which is determined by the difference between energy intake and exercise energy expenditure, is affected by selected environmental and energetic stresses (e.g., high-altitude, exercise, diet/nutrition). Systemic energy deficits have implications for the regulation of organ-specific metabolism. This thesis provides novel insights for integrative brain, skeletal muscle, and systemic substrate oxidation and relative fuel utilization in the context of environmental and energetic stress (e.g., high-altitude, exercise, nutritional caloric deficits). Experiments included: metabolism in the brain in response to CO2; the brain’s inflammatory response to maximal exercise following 6-8 days of acclimatization at 3,800 m; and a diet intervention in females involving 14-days of effectively 50% caloric restriction while maintaining 8 hours of endurance training per week.
M3 - Ph.D. thesis
BT - Substrate utilization in the brain and skeletal muscle during environmental and energetic stress in humans
PB - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
ER -
ID: 379646427