Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein–Barr virus encephalitis with lesion of sleep-wake regulation system

Sodium oxybate (Xyrem) treatment in severely sleep-deprived child with Epstein–Barr virus encephalitis with lesion of sleep-wake regulation system: a case report

Research output: Contribution to journal › Journal article › Research › peer-review

Malene Landbo Børresen
Kaare Engell Lundstrøm
Marianne Ifversen
Jennum, Poul

We present the effect of exogenous sodium oxybate (GHB) in a severely tormented boy unable to sleep and unable to be anesthetized due to a lesion in the sleep initiation system involving the tracks between the ventrolateral preoptic nucleus and the reticular system. We bypassed the system by using sodium oxybate's effect on the cortical GHB and GABA_B receptors involved in the initiation and maintenance of sleep.

Original language	English
Journal	Sleep Medicine
Volume	62
Pages (from-to)	29-31
ISSN	1389-9457
DOIs	https://doi.org/10.1016/j.sleep.2019.03.020
Publication status	Published - Oct 2019

Research areas

Duncan's disease, GABA, Gamma-hydroxybutyrate, GHB, Hemophagocytic lymphohistiocytosis, X-linked lymphoproliferative disease (XLP)

ID: 241998012