Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study

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Standard

Smoking and the development of allergic sensitization to aeroallergens in adults : a prospective population-based study. The Copenhagen Allergy Study. / Linneberg, A; Nielsen, N H; Madsen, F; Frølund, L; Dirksen, A; Jørgensen, T.

In: Allergy, Vol. 56, No. 4, 04.2001, p. 328-32.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linneberg, A, Nielsen, NH, Madsen, F, Frølund, L, Dirksen, A & Jørgensen, T 2001, 'Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study', Allergy, vol. 56, no. 4, pp. 328-32.

APA

Linneberg, A., Nielsen, N. H., Madsen, F., Frølund, L., Dirksen, A., & Jørgensen, T. (2001). Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study. Allergy, 56(4), 328-32.

Vancouver

Linneberg A, Nielsen NH, Madsen F, Frølund L, Dirksen A, Jørgensen T. Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study. Allergy. 2001 Apr;56(4):328-32.

Author

Linneberg, A ; Nielsen, N H ; Madsen, F ; Frølund, L ; Dirksen, A ; Jørgensen, T. / Smoking and the development of allergic sensitization to aeroallergens in adults : a prospective population-based study. The Copenhagen Allergy Study. In: Allergy. 2001 ; Vol. 56, No. 4. pp. 328-32.

Bibtex

@article{3df8195ce51e4862a3a26a48f5033ca9,
title = "Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study",
abstract = "BACKGROUND: Several cross-sectional population-based studies have reported a negative association between smoking and allergic sensitization to aeroallergens. In a prospective study, we investigated the association between smoking and the development (incidence) of allergic sensitization as reflected by skin prick test (SPT) positivity and specific IgE positivity.METHODS: Participants in a population-based study of 15 69-year-olds in 1990 were invited to a follow-up in 1998. Thus, SPT positivity and specific IgE positivity to common aeroallergens were assessed in 734 subjects (participation rate: 69.0%) on two occasions 8 years apart. The effect of smoking on the development of allergic sensitization was adjusted for potential confounders such as age, sex, family history of hay fever, educational level, and total IgE.RESULTS: During the follow-up period, 58 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. The risk of developing SPT positivity (adjusted odds ratio: 0.45, 95% CI 0.21-0.98) and specific IgE positivity (adjusted odds ratio: 0.62, 95%, CI 0.26-1.49) was lower among sustained smokers than never-smokers.CONCLUSIONS: In this adult population, sustained smoking was negatively associated with the development of allergic sensitization to aeroallergens during an 8-year follow-up. This negative association, if real, might be due to an immunosuppressive effect of smoking.",
keywords = "Adolescent, Adult, Aged, Air Pollution, Allergens, Confidence Intervals, Denmark, Female, Follow-Up Studies, Humans, Immunization, Immunoglobulin E, Incidence, Male, Middle Aged, Odds Ratio, Pollen, Prospective Studies, Skin Tests, Smoking, Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "A Linneberg and Nielsen, {N H} and F Madsen and L Fr{\o}lund and A Dirksen and T J{\o}rgensen",
year = "2001",
month = apr,
language = "English",
volume = "56",
pages = "328--32",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "4",

}

RIS

TY - JOUR

T1 - Smoking and the development of allergic sensitization to aeroallergens in adults

T2 - a prospective population-based study. The Copenhagen Allergy Study

AU - Linneberg, A

AU - Nielsen, N H

AU - Madsen, F

AU - Frølund, L

AU - Dirksen, A

AU - Jørgensen, T

PY - 2001/4

Y1 - 2001/4

N2 - BACKGROUND: Several cross-sectional population-based studies have reported a negative association between smoking and allergic sensitization to aeroallergens. In a prospective study, we investigated the association between smoking and the development (incidence) of allergic sensitization as reflected by skin prick test (SPT) positivity and specific IgE positivity.METHODS: Participants in a population-based study of 15 69-year-olds in 1990 were invited to a follow-up in 1998. Thus, SPT positivity and specific IgE positivity to common aeroallergens were assessed in 734 subjects (participation rate: 69.0%) on two occasions 8 years apart. The effect of smoking on the development of allergic sensitization was adjusted for potential confounders such as age, sex, family history of hay fever, educational level, and total IgE.RESULTS: During the follow-up period, 58 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. The risk of developing SPT positivity (adjusted odds ratio: 0.45, 95% CI 0.21-0.98) and specific IgE positivity (adjusted odds ratio: 0.62, 95%, CI 0.26-1.49) was lower among sustained smokers than never-smokers.CONCLUSIONS: In this adult population, sustained smoking was negatively associated with the development of allergic sensitization to aeroallergens during an 8-year follow-up. This negative association, if real, might be due to an immunosuppressive effect of smoking.

AB - BACKGROUND: Several cross-sectional population-based studies have reported a negative association between smoking and allergic sensitization to aeroallergens. In a prospective study, we investigated the association between smoking and the development (incidence) of allergic sensitization as reflected by skin prick test (SPT) positivity and specific IgE positivity.METHODS: Participants in a population-based study of 15 69-year-olds in 1990 were invited to a follow-up in 1998. Thus, SPT positivity and specific IgE positivity to common aeroallergens were assessed in 734 subjects (participation rate: 69.0%) on two occasions 8 years apart. The effect of smoking on the development of allergic sensitization was adjusted for potential confounders such as age, sex, family history of hay fever, educational level, and total IgE.RESULTS: During the follow-up period, 58 and 33 subjects developed SPT positivity and specific IgE positivity, respectively. The risk of developing SPT positivity (adjusted odds ratio: 0.45, 95% CI 0.21-0.98) and specific IgE positivity (adjusted odds ratio: 0.62, 95%, CI 0.26-1.49) was lower among sustained smokers than never-smokers.CONCLUSIONS: In this adult population, sustained smoking was negatively associated with the development of allergic sensitization to aeroallergens during an 8-year follow-up. This negative association, if real, might be due to an immunosuppressive effect of smoking.

KW - Adolescent

KW - Adult

KW - Aged

KW - Air Pollution

KW - Allergens

KW - Confidence Intervals

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunization

KW - Immunoglobulin E

KW - Incidence

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Pollen

KW - Prospective Studies

KW - Skin Tests

KW - Smoking

KW - Clinical Trial

KW - Comparative Study

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 11284801

VL - 56

SP - 328

EP - 332

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 4

ER -

ID: 173164245