Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease
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Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease. / Christensen, Julie Anja Engelhard; Jennum, Poul; Koch, Henriette; Frandsen, Rune; Zoetmulder, Marielle; Arvastson, Lars; Christensen, Søren Rahn; Sorensen, Helge Bjarrup Dissing.
In: Clinical Neurophysiology, Vol. 127, No. 1, 01.2016, p. 537-43.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sleep stability and transitions in patients with idiopathic REM sleep behavior disorder and patients with Parkinson's disease
AU - Christensen, Julie Anja Engelhard
AU - Jennum, Poul
AU - Koch, Henriette
AU - Frandsen, Rune
AU - Zoetmulder, Marielle
AU - Arvastson, Lars
AU - Christensen, Søren Rahn
AU - Sorensen, Helge Bjarrup Dissing
N1 - Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
PY - 2016/1
Y1 - 2016/1
N2 - OBJECTIVE: Patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) are at high risk of developing Parkinson's disease (PD). As wake/sleep-regulation is thought to involve neurons located in the brainstem and hypothalamic areas, we hypothesize that the neurodegeneration in iRBD/PD is likely to affect wake/sleep and REM/non-REM (NREM) sleep transitions.METHODS: We determined the frequency of wake/sleep and REM/NREM sleep transitions and the stability of wake (W), REM and NREM sleep as measured by polysomnography (PSG) in 27 patients with PD, 23 patients with iRBD, 25 patients with periodic leg movement disorder (PLMD) and 23 controls. Measures were computed based on manual scorings and data-driven labeled sleep staging.RESULTS: Patients with PD showed significantly lower REM stability than controls and patients with PLMD. Patients with iRBD had significantly lower REM stability compared with controls. Patients with PD and RBD showed significantly lower NREM stability and significantly more REM/NREM transitions than controls.CONCLUSIONS: We conclude that W, NREM and REM stability and transitions are progressively affected in iRBD and PD, probably reflecting the successive involvement of brain stem areas from early on in the disease.SIGNIFICANCE: Sleep stability and transitions determined by a data-driven approach could support the evaluation of iRBD and PD patients.
AB - OBJECTIVE: Patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) are at high risk of developing Parkinson's disease (PD). As wake/sleep-regulation is thought to involve neurons located in the brainstem and hypothalamic areas, we hypothesize that the neurodegeneration in iRBD/PD is likely to affect wake/sleep and REM/non-REM (NREM) sleep transitions.METHODS: We determined the frequency of wake/sleep and REM/NREM sleep transitions and the stability of wake (W), REM and NREM sleep as measured by polysomnography (PSG) in 27 patients with PD, 23 patients with iRBD, 25 patients with periodic leg movement disorder (PLMD) and 23 controls. Measures were computed based on manual scorings and data-driven labeled sleep staging.RESULTS: Patients with PD showed significantly lower REM stability than controls and patients with PLMD. Patients with iRBD had significantly lower REM stability compared with controls. Patients with PD and RBD showed significantly lower NREM stability and significantly more REM/NREM transitions than controls.CONCLUSIONS: We conclude that W, NREM and REM stability and transitions are progressively affected in iRBD and PD, probably reflecting the successive involvement of brain stem areas from early on in the disease.SIGNIFICANCE: Sleep stability and transitions determined by a data-driven approach could support the evaluation of iRBD and PD patients.
KW - Aged
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Parkinson Disease
KW - Polysomnography
KW - REM Sleep Behavior Disorder
KW - Sleep Stages
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.clinph.2015.03.006
DO - 10.1016/j.clinph.2015.03.006
M3 - Journal article
C2 - 25843013
VL - 127
SP - 537
EP - 543
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 1
ER -
ID: 164133297