Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a PET study with nitric oxide and cyclooxygenase inhibition
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Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a PET study with nitric oxide and cyclooxygenase inhibition. / Heinonen, Ilkka; Saltin, Bengt; Kemppainen, Jukka; Sipilä, Hannu T; Oikonen, Vesa; Nuutila, Pirjo; Knuuti, Juhani; Kalliokoski, Kari; Hellsten, Ylva.
In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 300, No. 4, 2011, p. H1510-H1517.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a PET study with nitric oxide and cyclooxygenase inhibition
AU - Heinonen, Ilkka
AU - Saltin, Bengt
AU - Kemppainen, Jukka
AU - Sipilä, Hannu T
AU - Oikonen, Vesa
AU - Nuutila, Pirjo
AU - Knuuti, Juhani
AU - Kalliokoski, Kari
AU - Hellsten, Ylva
N1 - CURIS 2011 5200 017
PY - 2011
Y1 - 2011
N2 - The aim of the present study was to determine the effect of nitric oxide and prostanoids on microcirculation and oxygen uptake specifically in the active skeletal muscle by use of positron emission tomography (PET). Healthy males performed 3 five min bouts of light knee-extensor exercise. Skeletal muscle blood flow and oxygen uptake were measured at rest and during the exercise using PET with H(2)O(15) and (15)O(2) during: 1) control conditions; 2) nitric oxide synthase (NOS) inhibition by arterial infusion of L-NMMA and 3) combined NOS and cyclooxygenase (COX) inhibition by arterial infusion of L-NMMA and indomethacin. At rest, inhibition of NOS alone and in combination with indomethacin reduced (P
AB - The aim of the present study was to determine the effect of nitric oxide and prostanoids on microcirculation and oxygen uptake specifically in the active skeletal muscle by use of positron emission tomography (PET). Healthy males performed 3 five min bouts of light knee-extensor exercise. Skeletal muscle blood flow and oxygen uptake were measured at rest and during the exercise using PET with H(2)O(15) and (15)O(2) during: 1) control conditions; 2) nitric oxide synthase (NOS) inhibition by arterial infusion of L-NMMA and 3) combined NOS and cyclooxygenase (COX) inhibition by arterial infusion of L-NMMA and indomethacin. At rest, inhibition of NOS alone and in combination with indomethacin reduced (P
U2 - 10.1152/ajpheart.00996.2010
DO - 10.1152/ajpheart.00996.2010
M3 - Journal article
C2 - 21257921
VL - 300
SP - H1510-H1517
JO - American Journal of Physiology: Heart and Circulatory Physiology
JF - American Journal of Physiology: Heart and Circulatory Physiology
SN - 0363-6135
IS - 4
ER -
ID: 32904790