Signals from the gut microbiota to distant organs in physiology and disease
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Signals from the gut microbiota to distant organs in physiology and disease. / Schroeder, Bjoern O; Bäckhed, Gert Fredrik.
In: Nature Medicine, Vol. 22, No. 10, 06.10.2016, p. 1079-1089.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Signals from the gut microbiota to distant organs in physiology and disease
AU - Schroeder, Bjoern O
AU - Bäckhed, Gert Fredrik
PY - 2016/10/6
Y1 - 2016/10/6
N2 - The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut-brain axis) and to host metabolism, as well as other functions of the host. This microbe-host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.
AB - The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut-brain axis) and to host metabolism, as well as other functions of the host. This microbe-host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.
U2 - 10.1038/nm.4185
DO - 10.1038/nm.4185
M3 - Journal article
C2 - 27711063
VL - 22
SP - 1079
EP - 1089
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 10
ER -
ID: 166941532