Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study
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Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. / Aronis, Konstantinos N; Vamvini, Maria T; Chamberland, John P; Sweeney, Laura L; Brennan, Aoife M; Magkos, Faidon; Mantzoros, Christos S.
In: Metabolism, Vol. 61, No. 4, 2012, p. 577-582.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study
AU - Aronis, Konstantinos N
AU - Vamvini, Maria T
AU - Chamberland, John P
AU - Sweeney, Laura L
AU - Brennan, Aoife M
AU - Magkos, Faidon
AU - Mantzoros, Christos S
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.
AB - Long-term consumption of walnuts is associated with lower cardiovascular disease risk in epidemiological studies, possibly through improvements in lipid profile and endothelial function. It remains to be elucidated how soon after initiation of walnut consumption beneficial effects on lipid profile and biomarkers of inflammation or vascular injury can be observed. Fifteen obese subjects (9 men and 6 women; age, 58 ± 2.5 years; body mass index, 36.6 ± 1.7 kg/m(2)) with the metabolic syndrome participated as inpatients in a randomized, double-blinded, placebo-controlled crossover study involving short-term placebo or walnut-enriched diet (48 g/d for 4 days). Apolipoproteins and markers of inflammation and vascular injury were measured before and after consumption of the experimental diets. Consumption of walnuts was associated with a statistically significant increase in serum apolipoprotein A concentrations (P = .03), but did not affect circulating levels of fetuin A, resistin, C-reactive protein, serum amyloid A, soluble intercellular adhesion molecules 1 and 3, soluble vascular cell adhesion protein 1, interleukins 6 and 8, tumor necrosis factor α, E-selectin, P-selectin, and thrombomodulin. Four days of walnut consumption (48 g/d) leads to mild increases in apolipoprotein A concentrations, changes that may precede and lead to the beneficial effects of walnuts on lipid profile in obese subjects with the metabolic syndrome.
KW - Adiponectin/blood
KW - Apolipoprotein A-I/blood
KW - C-Reactive Protein/metabolism
KW - Cell Adhesion Molecules/blood
KW - Cross-Over Studies
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Interleukins/blood
KW - Juglans
KW - Male
KW - Metabolic Syndrome/blood
KW - Middle Aged
KW - Obesity/blood
KW - Resistin/blood
KW - Selectins/blood
KW - Serum Amyloid A Protein/metabolism
KW - Statistics, Nonparametric
KW - Thrombomodulin/blood
KW - Tumor Necrosis Factor-alpha/blood
KW - Vascular Cell Adhesion Molecule-1/blood
KW - alpha-2-HS-Glycoprotein/metabolism
U2 - 10.1016/j.metabol.2011.09.008
DO - 10.1016/j.metabol.2011.09.008
M3 - Journal article
C2 - 22075273
VL - 61
SP - 577
EP - 582
JO - Metabolism
JF - Metabolism
SN - 0026-0495
IS - 4
ER -
ID: 290036168