Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children
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Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children. / Kjaer, T W; Faurholt-Jepsen, Daniel; Mehta, K M; Christensen, V B; Epel, E; Lin, J; Blackburn, E; Wojcicki, J M.
In: Clinical obesity, Vol. 8, No. 2, 01.04.2018, p. 88-94.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Shorter preschool, leukocyte telomere length is associated with obesity at age 9 in Latino children
AU - Kjaer, T W
AU - Faurholt-Jepsen, Daniel
AU - Mehta, K M
AU - Christensen, V B
AU - Epel, E
AU - Lin, J
AU - Blackburn, E
AU - Wojcicki, J M
N1 - CURIS 2018 NEXS 243
PY - 2018/4/1
Y1 - 2018/4/1
N2 - The aim of this study was to determine the potential role of leukocyte telomere length as a biomarker for development of childhood obesity in a low‐income Latino population. A birth cohort of Latino children (N = 201) in San Francisco (recruited May 2006–May 2007) was followed until age 9 and assessed annually for obesity and dietary intake. Leukocyte telomere length was measured at 4 and 5 years (n = 102) and assessed as a predictor for obesity at age 9, adjusting for known risk factors. Furthermore, leukocyte telomere length at age 4 and 5 was evaluated as a possible mediator of the relationship between excessive sugar‐sweetened beverage consumption and obesity at age 9. Shorter leukocyte telomere length in preschoolers was associated with obesity at age 9 (adjusted odds ratio 0.35, 95% confidence interval 0.13–0.94) after adjustment for known risk factors. Telomere length mediated 11% of the relationship between excessive sugar‐sweetened beverage consumption and obesity. Shorter leukocyte telomere length may be an indicator of future obesity risk in high‐risk populations as it is particularly sensitive to damage from oxidative stress exposure, including those from sugar‐sweetened beverages.
AB - The aim of this study was to determine the potential role of leukocyte telomere length as a biomarker for development of childhood obesity in a low‐income Latino population. A birth cohort of Latino children (N = 201) in San Francisco (recruited May 2006–May 2007) was followed until age 9 and assessed annually for obesity and dietary intake. Leukocyte telomere length was measured at 4 and 5 years (n = 102) and assessed as a predictor for obesity at age 9, adjusting for known risk factors. Furthermore, leukocyte telomere length at age 4 and 5 was evaluated as a possible mediator of the relationship between excessive sugar‐sweetened beverage consumption and obesity at age 9. Shorter leukocyte telomere length in preschoolers was associated with obesity at age 9 (adjusted odds ratio 0.35, 95% confidence interval 0.13–0.94) after adjustment for known risk factors. Telomere length mediated 11% of the relationship between excessive sugar‐sweetened beverage consumption and obesity. Shorter leukocyte telomere length may be an indicator of future obesity risk in high‐risk populations as it is particularly sensitive to damage from oxidative stress exposure, including those from sugar‐sweetened beverages.
KW - Childhood obesity
KW - Latinos
KW - Leukocyte telomere length
KW - Sugar-sweetened beverages
U2 - 10.1111/cob.12233
DO - 10.1111/cob.12233
M3 - Journal article
C2 - 29271129
VL - 8
SP - 88
EP - 94
JO - Clinical Obesity
JF - Clinical Obesity
SN - 1758-8103
IS - 2
ER -
ID: 200334320