Sex differences in the prognosis of nonsustained ventricular tachycardia detected on Holter recording
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Sex differences in the prognosis of nonsustained ventricular tachycardia detected on Holter recording. / Christiansen, Philip Bonde; Larsen, Bjørn Strøier; Hadad, Rakin; Nielsen, Olav Wendelboe; Dominguez Vall-Lamora, Maria Helena; Prescott, Eva; Galatius, Søren; Rasmusen, Hanne Kruuse; Davidsen, Ulla; Karlsen, Finn Michael; Højberg, Søren; Bang, Casper N.; Schramm, Tina Ken; Tfelt-Hansen, Jacob; Sajadieh, Ahmad.
In: Heart Rhythm O2, Vol. 5, No. 7, 2024, p. 427-434.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sex differences in the prognosis of nonsustained ventricular tachycardia detected on Holter recording
AU - Christiansen, Philip Bonde
AU - Larsen, Bjørn Strøier
AU - Hadad, Rakin
AU - Nielsen, Olav Wendelboe
AU - Dominguez Vall-Lamora, Maria Helena
AU - Prescott, Eva
AU - Galatius, Søren
AU - Rasmusen, Hanne Kruuse
AU - Davidsen, Ulla
AU - Karlsen, Finn Michael
AU - Højberg, Søren
AU - Bang, Casper N.
AU - Schramm, Tina Ken
AU - Tfelt-Hansen, Jacob
AU - Sajadieh, Ahmad
N1 - Publisher Copyright: © 2024 Heart Rhythm Society
PY - 2024
Y1 - 2024
N2 - Background: Nonsustained ventricular tachycardia (NSVT) is a common finding during cardiac evaluation and has been linked to increased mortality. While some studies report a sex difference, most data stem from research cohorts. Objective: This study aimed to assess the prognostic significance of NSVT in a real-life outpatient clinic, focusing on sex differences in mortality. Methods: Analysis was performed on a cohort of consecutive patients referred to 48-hour Holter monitoring between 2009 and 2011 at Copenhagen University Hospital – Bispebjerg. Indications for Holter monitoring included palpitations, dizziness, syncope, or arrhythmia testing. Baseline characteristics, blood tests, echocardiography results, and mortality data were obtained from electronic patient records. Results: A total of 762 females (mean age 59 ± 18 years) and 693 males (mean age 59 ± 17 years) were enrolled. At least 1 episode of NSVT was detected in 9.7% of females and 20.6% of males. The median follow-up was 8.3 years. A total of 20% of females and 24% of males died during follow-up. In multivariable models, NSVT was linked to mortality in males (hazard ratio [HR] 1.6, 95% confidence interval [CI] 1.1–2.3) but not in females (HR 1.2, 95% CI 0.7–2.1). In case-control pairs matched on the propensity of being male conditional on relevant risk factors, NSVT was again linked to mortality in males (HR 3.1, 95% CI 2.0–4.8) but not in females (HR 1.4, 95% CI 0.8–2.4). Conclusion: In consecutive patients referred to symptom driven Holter monitoring, NSVT was associated with elevated all-cause mortality in males but not in females. These results can contribute to the risk assessment of patients presenting with NSVT.
AB - Background: Nonsustained ventricular tachycardia (NSVT) is a common finding during cardiac evaluation and has been linked to increased mortality. While some studies report a sex difference, most data stem from research cohorts. Objective: This study aimed to assess the prognostic significance of NSVT in a real-life outpatient clinic, focusing on sex differences in mortality. Methods: Analysis was performed on a cohort of consecutive patients referred to 48-hour Holter monitoring between 2009 and 2011 at Copenhagen University Hospital – Bispebjerg. Indications for Holter monitoring included palpitations, dizziness, syncope, or arrhythmia testing. Baseline characteristics, blood tests, echocardiography results, and mortality data were obtained from electronic patient records. Results: A total of 762 females (mean age 59 ± 18 years) and 693 males (mean age 59 ± 17 years) were enrolled. At least 1 episode of NSVT was detected in 9.7% of females and 20.6% of males. The median follow-up was 8.3 years. A total of 20% of females and 24% of males died during follow-up. In multivariable models, NSVT was linked to mortality in males (hazard ratio [HR] 1.6, 95% confidence interval [CI] 1.1–2.3) but not in females (HR 1.2, 95% CI 0.7–2.1). In case-control pairs matched on the propensity of being male conditional on relevant risk factors, NSVT was again linked to mortality in males (HR 3.1, 95% CI 2.0–4.8) but not in females (HR 1.4, 95% CI 0.8–2.4). Conclusion: In consecutive patients referred to symptom driven Holter monitoring, NSVT was associated with elevated all-cause mortality in males but not in females. These results can contribute to the risk assessment of patients presenting with NSVT.
KW - Holter ECG
KW - Mortality
KW - Nonsustained ventricular tachycardia
KW - Premature ventricular complexes
KW - Prognosis
KW - Sex differences
KW - Ventricular arrythmia
U2 - 10.1016/j.hroo.2024.05.007
DO - 10.1016/j.hroo.2024.05.007
M3 - Journal article
AN - SCOPUS:85197588141
VL - 5
SP - 427
EP - 434
JO - Heart Rhythm O2
JF - Heart Rhythm O2
SN - 2666-5018
IS - 7
ER -
ID: 399239137