Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction
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Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction. / Jensen, L T; Hørslev-Petersen, K; Toft, P; Bentsen, K D; Grande, P; Simonsen, E E; Lorenzen, I.
In: Circulation. Supplement, Vol. 81, No. 1, 01.1990, p. 52-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Serum aminoterminal type III procollagen peptide reflects repair after acute myocardial infarction
AU - Jensen, L T
AU - Hørslev-Petersen, K
AU - Toft, P
AU - Bentsen, K D
AU - Grande, P
AU - Simonsen, E E
AU - Lorenzen, I
PY - 1990/1
Y1 - 1990/1
N2 - In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p less than 0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (p = 0.60, p = 0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.
AB - In 16 patients with acute myocardial infarction and in 15 controls, procollagen type III aminoterminal peptide in serum (PIIINP) was measured consecutively. Serum PIIINP was increased on the second to third postinfarction day (p less than 0.01) and remained elevated for more than 4 months. Peak values were observed on the third to seventh postinfarction day. The individual peak changes were correlated to infarction size calculated from serum CK-MB and serum lactate dehydrogenase (p = 0.60, p = 0.02). The changes in distribution of PIIINP-related antigens in serum after gel chromatography were similar to changes observed during wound healing in humans. PIIINP is cleaved off procollagen type III during the biosynthesis of type III collagen, which characterizes the early stages of repair and inflammation. Our findings suggest that serum PIIINP reflects the repair processes and scar formation following acute myocardial infarction. The serum PIIINP alterations in acute myocardial infarction differ essentially from the changes in myocardial enzymes reflecting myocardial injury. Serum PIIINP may therefore provide new and clinically relevant information on the healing of myocardial infarction.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Chromatography, Gel
KW - Female
KW - Heart Aneurysm
KW - Heart Septum
KW - Heart Ventricles
KW - Humans
KW - Male
KW - Middle Aged
KW - Myocardial Infarction
KW - Peptide Fragments
KW - Procollagen
KW - Wound Healing
KW - Case Reports
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - Journal article
C2 - 2297848
VL - 81
SP - 52
EP - 57
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 1
ER -
ID: 168533664