Serotonin transporters in dopamine transporter imaging: a head-to-head comparison of dopamine transporter SPECT radioligands 123I-FP-CIT and 123I-PE2I
Research output: Contribution to journal › Journal article › Research › peer-review
Current SPECT radioligands available for in vivo imaging of the dopamine transporter (DAT) also show affinity for monoamine transporters other than DAT, especially the serotonin transporter (SERT). The effect of this lack of selectivity for in vivo imaging is unknown. In this study, we compared the SPECT radioligands (123)I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl)nortropane ((123)I-FP-CIT) and (123)I-N-(3-iodoprop-2E-enyl)-2-ß-carbomethoxy-3ß-(4-methylphenyl) nortropane ((123)I-PE2I), which has a 10-fold higher selectivity than (123)I-FP-CIT for DAT versus SERT [corrected].
Original language | English |
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Journal | Journal of Nuclear Medicine |
Volume | 51 |
Issue number | 12 |
Pages (from-to) | 1885-91 |
Number of pages | 7 |
ISSN | 0161-5505 |
DOIs | |
Publication status | Published - 1 Dec 2010 |
ID: 34094276