Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

Research output: Contribution to journal › Letter › Research › peer-review

Standard

Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor. / Jäger, Anna; Knap, D.M.; Nielsen, Birgitte; Stafford, G. I.; van Staden, J.

In: South African Journal of Botany, Vol. 78, 01.2012, p. 312–314.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Jäger, A, Knap, DM, Nielsen, B, Stafford, GI & van Staden, J 2012, 'Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor', South African Journal of Botany, vol. 78, pp. 312–314. https://doi.org/10.1016/j.sajb.2011.10.002

APA

Jäger, A., Knap, D. M., Nielsen, B., Stafford, G. I., & van Staden, J. (2012). Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor. South African Journal of Botany, 78, 312–314. https://doi.org/10.1016/j.sajb.2011.10.002

Vancouver

Jäger A, Knap DM, Nielsen B, Stafford GI, van Staden J. Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor. South African Journal of Botany. 2012 Jan;78:312–314. https://doi.org/10.1016/j.sajb.2011.10.002

Author

Jäger, Anna ; Knap, D.M. ; Nielsen, Birgitte ; Stafford, G. I. ; van Staden, J. / Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor. In: South African Journal of Botany. 2012 ; Vol. 78. pp. 312–314.

Bibtex

@article{0fd14f1add054023bd2c6391ad8d116c,

title = "Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor",

abstract = "Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.",

author = "Anna J{\"a}ger and D.M. Knap and Birgitte Nielsen and Stafford, {G. I.} and {van Staden}, J.",

year = "2012",

month = jan,

doi = "10.1016/j.sajb.2011.10.002",

language = "English",

volume = "78",

pages = "312–314",

journal = "South African Journal of Botany",

issn = "0254-6299",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

AU - Jäger, Anna

AU - Knap, D.M.

AU - Nielsen, Birgitte

AU - Stafford, G. I.

AU - van Staden, J.

PY - 2012/1

Y1 - 2012/1

N2 - Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.

AB - Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.

U2 - 10.1016/j.sajb.2011.10.002

DO - 10.1016/j.sajb.2011.10.002

M3 - Letter

VL - 78

SP - 312

EP - 314

JO - South African Journal of Botany

JF - South African Journal of Botany

SN - 0254-6299

ER -

ID: 40575555