Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor
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Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor. / Jäger, Anna; Knap, D.M.; Nielsen, Birgitte; Stafford, G. I.; van Staden, J.
In: South African Journal of Botany, Vol. 78, 01.2012, p. 312–314.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor
AU - Jäger, Anna
AU - Knap, D.M.
AU - Nielsen, Birgitte
AU - Stafford, G. I.
AU - van Staden, J.
PY - 2012/1
Y1 - 2012/1
N2 - Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.
AB - Species of Searsia are used in traditional medicine to treat epilepsy. Previous studies on S. dentata and S. pyroides have shown that this is likely mediated via the N-methyl-d-aspartic acid (NMDA) receptor. Ethanolic extracts of leaves of six Searsia species were tested in a binding assay for affinity to the NMDA-receptor. S. dentata, S. gerrardii, S. glauca, S. natalensis, S. pentheri and S. pyroides all contained compounds with affinity to the NMDA-receptor. The species with the best affinity was S. pentheri. This might make it possible to use the Searsia species interchangeably, so the more accessible Searsia species can be used in traditional medicine.
U2 - 10.1016/j.sajb.2011.10.002
DO - 10.1016/j.sajb.2011.10.002
M3 - Letter
VL - 78
SP - 312
EP - 314
JO - South African Journal of Botany
JF - South African Journal of Botany
SN - 0254-6299
ER -
ID: 40575555