Screening of KCNN3 in patients with early-onset lone atrial fibrillation
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Screening of KCNN3 in patients with early-onset lone atrial fibrillation. / Olesen, Morten Sig; Jabbari, Javad; Holst, Anders G; Nielsen, Jonas B; Steinbrüchel, Daniel A; Jespersen, Thomas; Haunsø, Stig; Svendsen, Jesper H; Jespersen, Thomas.
In: Europace, Vol. 13, No. 7, 2011, p. 963-967.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Screening of KCNN3 in patients with early-onset lone atrial fibrillation
AU - Olesen, Morten Sig
AU - Jabbari, Javad
AU - Holst, Anders G
AU - Nielsen, Jonas B
AU - Steinbrüchel, Daniel A
AU - Jespersen, Thomas
AU - Haunsø, Stig
AU - Svendsen, Jesper H
AU - Jespersen, Thomas
PY - 2011
Y1 - 2011
N2 - Aims The aim of this study was to screen KCNN3 encoding the small-conductance calcium-activated K(+) channel (SK3) in lone atrial fibrillation patients. Atrial fibrillation (AF) is the most common cardiac arrhythmia. A genome-wide association study has recently associated an intronic single-nucleotide polymorphism (SNP) in KCNN3 with lone AF. Methods and results We sequenced the coding region and splice junctions of KCNN3 in 209 early-onset lone AF patients, screening for variations. A group of 208 healthy blood donors with normal ECGs and without cardiac symptoms were used as controls. All patients and controls were of Danish ethnicity. No mutations were found in the coding regions or splice sites of KCNN3. We found one known exonic synonymous SNP (rs1131820) in KCNN3 that was associated with AF. Both the genotype distribution and allele frequencies of SNP rs1131820 were significantly different between the AF cases and controls (P(Genotype)= 0.047 and P(Allele)= 0.027). Being a homozygous carrier of the major allele (GG) vs. the minor allele (AA) of rs1131820 was associated with an odds ratio of 2.85 (95% CI 1.13-7.18, P = 0.026) for lone AF. Conclusions In this study of 209 young lone AF patients, we found no mutations in the exons or splice sites of KCNN3, but we found an association between the synonymous SNP rs1131820 in KCNN3 and lone AF.
AB - Aims The aim of this study was to screen KCNN3 encoding the small-conductance calcium-activated K(+) channel (SK3) in lone atrial fibrillation patients. Atrial fibrillation (AF) is the most common cardiac arrhythmia. A genome-wide association study has recently associated an intronic single-nucleotide polymorphism (SNP) in KCNN3 with lone AF. Methods and results We sequenced the coding region and splice junctions of KCNN3 in 209 early-onset lone AF patients, screening for variations. A group of 208 healthy blood donors with normal ECGs and without cardiac symptoms were used as controls. All patients and controls were of Danish ethnicity. No mutations were found in the coding regions or splice sites of KCNN3. We found one known exonic synonymous SNP (rs1131820) in KCNN3 that was associated with AF. Both the genotype distribution and allele frequencies of SNP rs1131820 were significantly different between the AF cases and controls (P(Genotype)= 0.047 and P(Allele)= 0.027). Being a homozygous carrier of the major allele (GG) vs. the minor allele (AA) of rs1131820 was associated with an odds ratio of 2.85 (95% CI 1.13-7.18, P = 0.026) for lone AF. Conclusions In this study of 209 young lone AF patients, we found no mutations in the exons or splice sites of KCNN3, but we found an association between the synonymous SNP rs1131820 in KCNN3 and lone AF.
U2 - 10.1093/europace/eur007
DO - 10.1093/europace/eur007
M3 - Journal article
C2 - 21398315
VL - 13
SP - 963
EP - 967
JO - Europace
JF - Europace
SN - 1099-5129
IS - 7
ER -
ID: 33013184