Safety and efficacy of a feed additive consisting of l-valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.)
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Safety and efficacy of a feed additive consisting of l-valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.). / Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Durjava, Mojca; Dusemund, Birgit; Kouba, Maryline; López-Alonso, Marta; Puente, Secundino López; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Sanz, Yolanda; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Herman, Lieve; Anguita, Montserrat; Tarrés-Call, Jordi; Firmino, Joana P.; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP).
In: EFSA Journal, Vol. 21, No. 7, e08104, 2023.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Safety and efficacy of a feed additive consisting of l-valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.)
AU - Bampidis, Vasileios
AU - Azimonti, Giovanna
AU - Bastos, Maria de Lourdes
AU - Christensen, Henrik
AU - Durjava, Mojca
AU - Dusemund, Birgit
AU - Kouba, Maryline
AU - López-Alonso, Marta
AU - Puente, Secundino López
AU - Marcon, Francesca
AU - Mayo, Baltasar
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Sanz, Yolanda
AU - Sanz, Yolanda
AU - Villa, Roberto Edoardo
AU - Woutersen, Ruud
AU - Herman, Lieve
AU - Anguita, Montserrat
AU - Tarrés-Call, Jordi
AU - Firmino, Joana P.
AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
N1 - Publisher Copyright: © 2023 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority.
PY - 2023
Y1 - 2023
N2 - Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-valine produced by fermentation using a non-genetically modified strain of Corynebacterium glutamicum (CGMCC 18932). l-Valine is intended to be used in feed and water for drinking as a nutritional additive, functional group amino acids, their salts and analogues, for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that l-valine produced by C. glutamicum CGMCC 18932 is considered safe for the target species when supplemented to the diet in appropriate amounts according to the nutritional needs of the target species. The use of l-valine produced using C. glutamicum CGMCC 18932 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using C. glutamicum CGMCC 18932 to be irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The FEEDAP Panel concluded that the l-valine produced by fermentation using C. glutamicum CGMCC 18932 is an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. To be as efficacious in ruminants as in non-ruminants, supplemental l-valine requires protection against ruminal degradation. The FEEDAP Panel expressed concerns on the use of amino acids in water for drinking for hygienic reasons.
AB - Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-valine produced by fermentation using a non-genetically modified strain of Corynebacterium glutamicum (CGMCC 18932). l-Valine is intended to be used in feed and water for drinking as a nutritional additive, functional group amino acids, their salts and analogues, for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that l-valine produced by C. glutamicum CGMCC 18932 is considered safe for the target species when supplemented to the diet in appropriate amounts according to the nutritional needs of the target species. The use of l-valine produced using C. glutamicum CGMCC 18932 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l-valine produced using C. glutamicum CGMCC 18932 to be irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The FEEDAP Panel concluded that the l-valine produced by fermentation using C. glutamicum CGMCC 18932 is an efficacious source of the essential amino acid l-valine for non-ruminant nutrition. To be as efficacious in ruminants as in non-ruminants, supplemental l-valine requires protection against ruminal degradation. The FEEDAP Panel expressed concerns on the use of amino acids in water for drinking for hygienic reasons.
KW - aminoacids
KW - Corynebacterium glutamicum
KW - efficacy
KW - l-valine
KW - nutritional additives
KW - safety
KW - their salts and analogues
U2 - 10.2903/j.efsa.2023.8104
DO - 10.2903/j.efsa.2023.8104
M3 - Journal article
C2 - 37448445
AN - SCOPUS:85165565283
VL - 21
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 7
M1 - e08104
ER -
ID: 367751854