Rubidium-82 PET imaging is feasible in a rat myocardial infarction model
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Rubidium-82 PET imaging is feasible in a rat myocardial infarction model. / Ghotbi, Adam Ali; Clemmensen, Andreas; Kyhl, Kasper; Follin, Bjarke; Hasbak, Philip; Engstrøm, Thomas; Ripa, Rasmus Sejersten; Kjaer, Andreas.
In: Journal of Nuclear Cardiology, Vol. 26, 2019, p. 798–809.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Rubidium-82 PET imaging is feasible in a rat myocardial infarction model
AU - Ghotbi, Adam Ali
AU - Clemmensen, Andreas
AU - Kyhl, Kasper
AU - Follin, Bjarke
AU - Hasbak, Philip
AU - Engstrøm, Thomas
AU - Ripa, Rasmus Sejersten
AU - Kjaer, Andreas
PY - 2019
Y1 - 2019
N2 - Background: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ( 82Rb) in a small-animal scanner using a rat myocardial infarct model. Methods: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure. 82Rb-PET and magnetic resonance imaging (MRI) were conducted before and after the intervention. Perfusion was compared to both left ventricle ejection fraction (LVEF) and infarct size assessed by MRI. Results: Follow-up global 82Rb-uptake correlated significantly with infarct size (infarct group: r = −0.81, P < 0.001 and reperfusion group: r = −0.61, P = 0.04). Only 82Rb-uptake in the infarct group correlated with LVEF. At follow-up, a higher segmental 82Rb-uptake in the infarct group was associated with better wall motion (β = 0.034, CI [0.028;0.039], P < 0.001, R 2 = 0.30), and inversely associated with scar transmurality (β = −2.4 [−2.6; −2.2], P < 0.001, R 2 = 0.59). The associations were similar for the reperfusion group. Conclusion: 82Rb-PET is feasible in small animal scanners despite the long positron range and enables fast and time-efficient myocardial perfusion imaging in rat models.
AB - Background: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ( 82Rb) in a small-animal scanner using a rat myocardial infarct model. Methods: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure. 82Rb-PET and magnetic resonance imaging (MRI) were conducted before and after the intervention. Perfusion was compared to both left ventricle ejection fraction (LVEF) and infarct size assessed by MRI. Results: Follow-up global 82Rb-uptake correlated significantly with infarct size (infarct group: r = −0.81, P < 0.001 and reperfusion group: r = −0.61, P = 0.04). Only 82Rb-uptake in the infarct group correlated with LVEF. At follow-up, a higher segmental 82Rb-uptake in the infarct group was associated with better wall motion (β = 0.034, CI [0.028;0.039], P < 0.001, R 2 = 0.30), and inversely associated with scar transmurality (β = −2.4 [−2.6; −2.2], P < 0.001, R 2 = 0.59). The associations were similar for the reperfusion group. Conclusion: 82Rb-PET is feasible in small animal scanners despite the long positron range and enables fast and time-efficient myocardial perfusion imaging in rat models.
KW - infarction
KW - magnetic resonance
KW - perfusion imaging
KW - rat myocardium
KW - rubidium-82 PET
KW - Small-animal heart
U2 - 10.1007/s12350-017-0994-9
DO - 10.1007/s12350-017-0994-9
M3 - Journal article
C2 - 28721647
VL - 26
SP - 798
EP - 809
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
ER -
ID: 184290466