Risk of cancer in relatives of patients with myelodysplastic neoplasia and acute leukemias
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Risk of cancer in relatives of patients with myelodysplastic neoplasia and acute leukemias. / Nitschke, Nikolaj Juul; Rostgaard, Klaus; Andersen, Mette Klarskov; Hjalgrim, Henrik; Grønbæk, Kirsten.
In: Cancer Epidemiology, Vol. 88, 102523, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Risk of cancer in relatives of patients with myelodysplastic neoplasia and acute leukemias
AU - Nitschke, Nikolaj Juul
AU - Rostgaard, Klaus
AU - Andersen, Mette Klarskov
AU - Hjalgrim, Henrik
AU - Grønbæk, Kirsten
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Background: The risk of cancer among relatives of patients with either myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) has not been thoroughly examined. Methods: We linked the Danish Civil Registration System with the Danish Cancer Registry, the Danish National Acute Leukemia Registry, and the Danish Myelodysplastic Syndrome Database to estimate the relative risk of cancer among relatives of patients with MDS/AML/ALL. We used standardized incidence ratios (SIRs), i.e., the ratio of observed to expected number of cancers among the relatives as a measure of relative risk. Results: We identified 13010 first-degree (FDR) and 22051 second-degree (SDR) relatives of 8386 patients with MDS/ALL/AML. Disregarding basal cell carcinoma (BCC), the relative risk for cancer overall was increased in both FDR (SIR=1.3; 95% confidence interval (CI) 1.1–1.4) and SDR (SIR=1.5; 95% CI 1.2–1.8). SIRs among FDRs were statistically significantly increased for malignant melanoma, BCC and for the combined groups of cancers of the male genital organs, urinary tract, and MDS/AML/ALL. Among SDRs, SIRs were statistically significantly increased for malignant melanoma, BCC, and cancers in the digestive organs and peritoneum. Conclusions: We observed an increased risk of cancer among FDR and SDR of patients with MDS/AML/ALL.
AB - Background: The risk of cancer among relatives of patients with either myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) has not been thoroughly examined. Methods: We linked the Danish Civil Registration System with the Danish Cancer Registry, the Danish National Acute Leukemia Registry, and the Danish Myelodysplastic Syndrome Database to estimate the relative risk of cancer among relatives of patients with MDS/AML/ALL. We used standardized incidence ratios (SIRs), i.e., the ratio of observed to expected number of cancers among the relatives as a measure of relative risk. Results: We identified 13010 first-degree (FDR) and 22051 second-degree (SDR) relatives of 8386 patients with MDS/ALL/AML. Disregarding basal cell carcinoma (BCC), the relative risk for cancer overall was increased in both FDR (SIR=1.3; 95% confidence interval (CI) 1.1–1.4) and SDR (SIR=1.5; 95% CI 1.2–1.8). SIRs among FDRs were statistically significantly increased for malignant melanoma, BCC and for the combined groups of cancers of the male genital organs, urinary tract, and MDS/AML/ALL. Among SDRs, SIRs were statistically significantly increased for malignant melanoma, BCC, and cancers in the digestive organs and peritoneum. Conclusions: We observed an increased risk of cancer among FDR and SDR of patients with MDS/AML/ALL.
KW - Acute leukemia
KW - ALL
KW - AML
KW - Epidemiology
KW - Familial risk of cancer
KW - Genetic
KW - MDS
KW - Myeloid neoplasms
U2 - 10.1016/j.canep.2024.102523
DO - 10.1016/j.canep.2024.102523
M3 - Journal article
C2 - 38198910
AN - SCOPUS:85182236933
VL - 88
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
M1 - 102523
ER -
ID: 380292664