Risk factors for survival in a university hospital population of dogs with epilepsy

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Risk factors for survival in a university hospital population of dogs with epilepsy. / Andersen, Nadia Fredsø; Koch, B. C.; Toft, N.; Berendt, Mette.

In: Journal of Veterinary Internal Medicine, Vol. 28, No. 6, 2014, p. 1782-1788.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Andersen, NF, Koch, BC, Toft, N & Berendt, M 2014, 'Risk factors for survival in a university hospital population of dogs with epilepsy', Journal of Veterinary Internal Medicine, vol. 28, no. 6, pp. 1782-1788. https://doi.org/10.1111/jvim.12443

APA

Andersen, N. F., Koch, B. C., Toft, N., & Berendt, M. (2014). Risk factors for survival in a university hospital population of dogs with epilepsy. Journal of Veterinary Internal Medicine, 28(6), 1782-1788. https://doi.org/10.1111/jvim.12443

Vancouver

Andersen NF, Koch BC, Toft N, Berendt M. Risk factors for survival in a university hospital population of dogs with epilepsy. Journal of Veterinary Internal Medicine. 2014;28(6):1782-1788. https://doi.org/10.1111/jvim.12443

Author

Andersen, Nadia Fredsø ; Koch, B. C. ; Toft, N. ; Berendt, Mette. / Risk factors for survival in a university hospital population of dogs with epilepsy. In: Journal of Veterinary Internal Medicine. 2014 ; Vol. 28, No. 6. pp. 1782-1788.

Bibtex

@article{2c0e3a69d63348f9b23c3d12251104e5,
title = "Risk factors for survival in a university hospital population of dogs with epilepsy",
abstract = "BACKGROUND: Although a common neurological disorder in dogs, long-term outcome of epilepsy is sparsely documented.OBJECTIVES: To investigate risk factors for survival and duration of survival in a population of dogs with idiopathic epilepsy or epilepsy associated with a known intracranial cause.ANIMALS: One hundred and two client owned dogs; 78 dogs with idiopathic epilepsy and 24 dogs with epilepsy associated with a known intracranial cause.METHODS: A retrospective hospital based study with follow-up. Dogs diagnosed with epilepsy between 2002 and 2008 were enrolled in the study. Owners were interviewed by telephone using a structured questionnaire addressing epilepsy status, treatment, death/alive, and cause of death.RESULTS: Median life span was 7.6 years, 9.2 years, and 5.8 years for all dogs, and dogs with idiopathic epilepsy or dogs with epilepsy associated with a known intracranial cause (P < .001), respectively. Survival time for dogs with idiopathic epilepsy was significantly (P = .0030) decreased for dogs euthanized because of epilepsy (median: 35 months) compared to dogs euthanized for other reasons (median: 67.5 months). Neutered male dogs with idiopathic epilepsy had a significant (P = .031) shorter survival (median: 38.5 months) after index seizure compared to intact male dogs (median: 71 months). Treatment with two antiepileptic drugs (AED's) did not negatively influence survival (P = .056).CONCLUSION AND CLINICAL IMPORTANCE: Dogs with idiopathic epilepsy can in many cases expect a life span close to what is reported for dogs in general. In dogs where mono-therapy is not sufficient, the need for treatment with two AED's is not linked to a poor prognosis.",
author = "Andersen, {Nadia Freds{\o}} and Koch, {B. C.} and N. Toft and Mette Berendt",
note = "Copyright {\circledC} 2014 by the American College of Veterinary Internal Medicine.",
year = "2014",
doi = "10.1111/jvim.12443",
language = "English",
volume = "28",
pages = "1782--1788",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Risk factors for survival in a university hospital population of dogs with epilepsy

AU - Andersen, Nadia Fredsø

AU - Koch, B. C.

AU - Toft, N.

AU - Berendt, Mette

N1 - Copyright © 2014 by the American College of Veterinary Internal Medicine.

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Although a common neurological disorder in dogs, long-term outcome of epilepsy is sparsely documented.OBJECTIVES: To investigate risk factors for survival and duration of survival in a population of dogs with idiopathic epilepsy or epilepsy associated with a known intracranial cause.ANIMALS: One hundred and two client owned dogs; 78 dogs with idiopathic epilepsy and 24 dogs with epilepsy associated with a known intracranial cause.METHODS: A retrospective hospital based study with follow-up. Dogs diagnosed with epilepsy between 2002 and 2008 were enrolled in the study. Owners were interviewed by telephone using a structured questionnaire addressing epilepsy status, treatment, death/alive, and cause of death.RESULTS: Median life span was 7.6 years, 9.2 years, and 5.8 years for all dogs, and dogs with idiopathic epilepsy or dogs with epilepsy associated with a known intracranial cause (P < .001), respectively. Survival time for dogs with idiopathic epilepsy was significantly (P = .0030) decreased for dogs euthanized because of epilepsy (median: 35 months) compared to dogs euthanized for other reasons (median: 67.5 months). Neutered male dogs with idiopathic epilepsy had a significant (P = .031) shorter survival (median: 38.5 months) after index seizure compared to intact male dogs (median: 71 months). Treatment with two antiepileptic drugs (AED's) did not negatively influence survival (P = .056).CONCLUSION AND CLINICAL IMPORTANCE: Dogs with idiopathic epilepsy can in many cases expect a life span close to what is reported for dogs in general. In dogs where mono-therapy is not sufficient, the need for treatment with two AED's is not linked to a poor prognosis.

AB - BACKGROUND: Although a common neurological disorder in dogs, long-term outcome of epilepsy is sparsely documented.OBJECTIVES: To investigate risk factors for survival and duration of survival in a population of dogs with idiopathic epilepsy or epilepsy associated with a known intracranial cause.ANIMALS: One hundred and two client owned dogs; 78 dogs with idiopathic epilepsy and 24 dogs with epilepsy associated with a known intracranial cause.METHODS: A retrospective hospital based study with follow-up. Dogs diagnosed with epilepsy between 2002 and 2008 were enrolled in the study. Owners were interviewed by telephone using a structured questionnaire addressing epilepsy status, treatment, death/alive, and cause of death.RESULTS: Median life span was 7.6 years, 9.2 years, and 5.8 years for all dogs, and dogs with idiopathic epilepsy or dogs with epilepsy associated with a known intracranial cause (P < .001), respectively. Survival time for dogs with idiopathic epilepsy was significantly (P = .0030) decreased for dogs euthanized because of epilepsy (median: 35 months) compared to dogs euthanized for other reasons (median: 67.5 months). Neutered male dogs with idiopathic epilepsy had a significant (P = .031) shorter survival (median: 38.5 months) after index seizure compared to intact male dogs (median: 71 months). Treatment with two antiepileptic drugs (AED's) did not negatively influence survival (P = .056).CONCLUSION AND CLINICAL IMPORTANCE: Dogs with idiopathic epilepsy can in many cases expect a life span close to what is reported for dogs in general. In dogs where mono-therapy is not sufficient, the need for treatment with two AED's is not linked to a poor prognosis.

U2 - 10.1111/jvim.12443

DO - 10.1111/jvim.12443

M3 - Journal article

C2 - 25252168

VL - 28

SP - 1782

EP - 1788

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 6

ER -

ID: 131110320