Richter’s transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study
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Richter’s transformation (RT) refers to the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Approximately, 2–10% of patients with CLL develop RT, most often as diffuse large B-cell lymphoma. To assess the incidence of RT, we examined risk factors for RT and death among patients with RT in a nationwide CLL cohort (from 2008 to 2016). Among 3772 patients, 113 had biopsy-proven RT. With a median follow-up of 4.3 years, the 5-year cumulative incidence of RT was 2.8%. Advanced Binet stage (B/C) (p<.001), unmutated IGHV (p<.001), and del(17p) (p<.001) were independently associated with risk of developing RT. Half of the patients with RT (49%) were treatment-naïve prior to transformation and demonstrated longer survival after RT compared to patients previously treated for CLL (6.1 vs. 2.8 years, p=.03). Whether this finding could be explained by a higher proportion of clonally unrelated RT among treatment-naïve patients, remain to be addressed.
Original language | English |
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Journal | Leukemia and Lymphoma |
Volume | 61 |
Issue number | 6 |
Pages (from-to) | 1435-1444 |
Number of pages | 10 |
ISSN | 1042-8194 |
DOIs | |
Publication status | Published - 2020 |
- Chronic lymphocytic leukemia, diffuse large B-cell lymphoma, Hodgkin lymphoma, prognostication, Richter’s transformation
Research areas
ID: 258323892