Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort

Research output: Contribution to journal › Journal article › Research › peer-review

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Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort. / Ozdemir, Selinay; Sears, Clara G.; Harrington, James M.; Poulsen, Aslak Harbo; Buckley, Jessie; Howe, Chanelle J.; James, Katherine A.; Tjonneland, Anne; Wellenius, Gregory A.; Raaschou-Nielsen, Ole; Meliker, Jaymie.

In: Toxics, Vol. 9, No. 11, 282, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ozdemir, S, Sears, CG, Harrington, JM, Poulsen, AH, Buckley, J, Howe, CJ, James, KA, Tjonneland, A, Wellenius, GA, Raaschou-Nielsen, O & Meliker, J 2021, 'Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort', Toxics, vol. 9, no. 11, 282. https://doi.org/10.3390/toxics9110282

APA

Ozdemir, S., Sears, C. G., Harrington, J. M., Poulsen, A. H., Buckley, J., Howe, C. J., James, K. A., Tjonneland, A., Wellenius, G. A., Raaschou-Nielsen, O., & Meliker, J. (2021). Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort. Toxics, 9(11), [282]. https://doi.org/10.3390/toxics9110282

Vancouver

Ozdemir S, Sears CG, Harrington JM, Poulsen AH, Buckley J, Howe CJ et al. Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort. Toxics. 2021;9(11). 282. https://doi.org/10.3390/toxics9110282

Author

Ozdemir, Selinay ; Sears, Clara G. ; Harrington, James M. ; Poulsen, Aslak Harbo ; Buckley, Jessie ; Howe, Chanelle J. ; James, Katherine A. ; Tjonneland, Anne ; Wellenius, Gregory A. ; Raaschou-Nielsen, Ole ; Meliker, Jaymie. / Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort. In: Toxics. 2021 ; Vol. 9, No. 11.

Bibtex

@article{fb9a7b8fdb9a44f5ba3e940e1e262041,

title = "Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort",

abstract = "Assays of urine biomarkers often use urine creatinine to account for urinary dilution, even though creatinine levels are influenced by underlying physiology and muscle catabolism. Urine osmolality—a measure of dissolved particles including ions, glucose, and urea—is thought to provide a more robust marker of urinary dilution but is seldom measured. The relationship between urine osmolality and creatinine is not well understood. We calculated correlation coefficients between urine creatinine and osmolality among 1375 members of a subcohort of the Danish Diet, Cancer, and Health Cohort, and within different subgroups. We used linear regression to relate creatinine with osmolality, and a lasso selection procedure to identify other variables that explain remaining variability in osmolality. Spearman correlation between urine creatinine and osmolality was strong overall (ρ = 0.90; 95% CI: 0.89–0.91) and in most subgroups. Linear regression showed that urine creatinine explained 60% of the variability in urine osmolality, with another 9% explained by urine thallium (Tl), cesium (Cs), and strontium (Sr). Urinary creatinine and osmolality are strongly correlated, although urine Tl, Cs, and Sr might help supplement urine creatinine for purposes of urine dilution adjustment when osmolality is not available.",

keywords = "Biomonitoring, Urine creatinine, Urine dilution, Urine normalization, Urine osmolality",

author = "Selinay Ozdemir and Sears, {Clara G.} and Harrington, {James M.} and Poulsen, {Aslak Harbo} and Jessie Buckley and Howe, {Chanelle J.} and James, {Katherine A.} and Anne Tjonneland and Wellenius, {Gregory A.} and Ole Raaschou-Nielsen and Jaymie Meliker",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/toxics9110282",

language = "English",

volume = "9",

journal = "Toxics",

issn = "2305-6304",

publisher = "MDPI AG",

number = "11",

}

RIS

TY - JOUR

T1 - Relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort

AU - Ozdemir, Selinay

AU - Sears, Clara G.

AU - Harrington, James M.

AU - Poulsen, Aslak Harbo

AU - Buckley, Jessie

AU - Howe, Chanelle J.

AU - James, Katherine A.

AU - Tjonneland, Anne

AU - Wellenius, Gregory A.

AU - Raaschou-Nielsen, Ole

AU - Meliker, Jaymie

PY - 2021

Y1 - 2021

N2 - Assays of urine biomarkers often use urine creatinine to account for urinary dilution, even though creatinine levels are influenced by underlying physiology and muscle catabolism. Urine osmolality—a measure of dissolved particles including ions, glucose, and urea—is thought to provide a more robust marker of urinary dilution but is seldom measured. The relationship between urine osmolality and creatinine is not well understood. We calculated correlation coefficients between urine creatinine and osmolality among 1375 members of a subcohort of the Danish Diet, Cancer, and Health Cohort, and within different subgroups. We used linear regression to relate creatinine with osmolality, and a lasso selection procedure to identify other variables that explain remaining variability in osmolality. Spearman correlation between urine creatinine and osmolality was strong overall (ρ = 0.90; 95% CI: 0.89–0.91) and in most subgroups. Linear regression showed that urine creatinine explained 60% of the variability in urine osmolality, with another 9% explained by urine thallium (Tl), cesium (Cs), and strontium (Sr). Urinary creatinine and osmolality are strongly correlated, although urine Tl, Cs, and Sr might help supplement urine creatinine for purposes of urine dilution adjustment when osmolality is not available.

AB - Assays of urine biomarkers often use urine creatinine to account for urinary dilution, even though creatinine levels are influenced by underlying physiology and muscle catabolism. Urine osmolality—a measure of dissolved particles including ions, glucose, and urea—is thought to provide a more robust marker of urinary dilution but is seldom measured. The relationship between urine osmolality and creatinine is not well understood. We calculated correlation coefficients between urine creatinine and osmolality among 1375 members of a subcohort of the Danish Diet, Cancer, and Health Cohort, and within different subgroups. We used linear regression to relate creatinine with osmolality, and a lasso selection procedure to identify other variables that explain remaining variability in osmolality. Spearman correlation between urine creatinine and osmolality was strong overall (ρ = 0.90; 95% CI: 0.89–0.91) and in most subgroups. Linear regression showed that urine creatinine explained 60% of the variability in urine osmolality, with another 9% explained by urine thallium (Tl), cesium (Cs), and strontium (Sr). Urinary creatinine and osmolality are strongly correlated, although urine Tl, Cs, and Sr might help supplement urine creatinine for purposes of urine dilution adjustment when osmolality is not available.

KW - Biomonitoring

KW - Urine creatinine

KW - Urine dilution

KW - Urine normalization

KW - Urine osmolality

U2 - 10.3390/toxics9110282

DO - 10.3390/toxics9110282

M3 - Journal article

C2 - 34822673

AN - SCOPUS:85119077468

VL - 9

JO - Toxics

JF - Toxics

SN - 2305-6304

IS - 11

M1 - 282

ER -

ID: 286487980