Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation
Research output: Contribution to journal › Journal article › Research › peer-review
The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.
| Original language | English |
|---|---|
| Journal | American Journal of Cardiology |
| Volume | 96 |
| Issue number | 3 |
| Pages (from-to) | 405-7 |
| Number of pages | 2 |
| ISSN | 0002-9149 |
| DOIs | |
| Publication status | Published - 2005 |
Bibliographical note
Keywords: Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Chi-Square Distribution; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Potassium Channels, Voltage-Gated; Risk Assessment
ID: 21258973