Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study
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Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study. / Ropele, Stefan; Seewann, Alexandra; Gouw, Alida A; van der Flier, Wiesje M; Schmidt, Reinhold; Pantoni, Leonardo; Inzitari, Domenico; Erkinjuntti, Timo; Scheltens, Philip; Wahlund, Lars O; Waldemar, Gunhild; Chabriat, Hugues; Ferro, José; Hennerici, Michael; O'Brien, John; Wallin, Anders; Langhorne, Peter; Visser, Marieke C; Barkhof, Frederik; Fazekas, Franz; LADIS study group.
In: Journal of Magnetic Resonance Imaging, Vol. 29, No. 2, 2009, p. 268-74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study
AU - Ropele, Stefan
AU - Seewann, Alexandra
AU - Gouw, Alida A
AU - van der Flier, Wiesje M
AU - Schmidt, Reinhold
AU - Pantoni, Leonardo
AU - Inzitari, Domenico
AU - Erkinjuntti, Timo
AU - Scheltens, Philip
AU - Wahlund, Lars O
AU - Waldemar, Gunhild
AU - Chabriat, Hugues
AU - Ferro, José
AU - Hennerici, Michael
AU - O'Brien, John
AU - Wallin, Anders
AU - Langhorne, Peter
AU - Visser, Marieke C
AU - Barkhof, Frederik
AU - Fazekas, Franz
AU - LADIS study group
N1 - Keywords: Aged; Aged, 80 and over; Analysis of Variance; Diffusion Magnetic Resonance Imaging; Female; Humans; Imaging, Three-Dimensional; Leukoaraiosis; Magnetic Resonance Imaging; Male; Severity of Illness Index
PY - 2009
Y1 - 2009
N2 - PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score. RESULTS: ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity. CONCLUSION: ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings.
AB - PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score. RESULTS: ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity. CONCLUSION: ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings.
U2 - 10.1002/jmri.21580
DO - 10.1002/jmri.21580
M3 - Journal article
C2 - 19161174
VL - 29
SP - 268
EP - 274
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 2
ER -
ID: 19978073