Pulmonary Arterial Wedge Pressure at Rest and During Exercise in Healthy Adults: A Systematic Review and Meta-analysis
Research output: Contribution to journal › Review › Research › peer-review
BACKGROUND: The pulmonary arterial wedge pressure (PAWP) response to exercise may unmask latent heart failure with preserved ejection fraction. There remains a lack of consensus over threshold values for PAWP during exercise. A systematic review of studies examining PAWP by means of right heart catheterization at rest and during exercise in healthy individuals was performed.
METHODS AND RESULTS: Relevant data derived from healthy volunteers were stratified by age (older than 40 years vs 40 years or younger) and sex. Three exercise intensities were predefined: light, moderate, and strenuous. Weighted means and weighted 95% confidence intervals (CIs) for the aggregate data were calculated. A total of 424 individuals from 32 unique studies were included, of which 19% (n = 82) were female. PAWP reached weighted mean and 95% CI values of 19 (17-21) and 17 (16-18) mm Hg at light and moderate exercise, respectively. The PAWP response to exercise was similar between men and women >40 years of age. However, exercise intensities were lower in women.
CONCLUSIONS: PAWP increases during exercise, reaching up to 20 mm Hg in adults >40 years of age. Older women achieve PAWP values similar to those of older men, but at lower intensities. Findings support a threshold of at least 25 mm Hg as an absolute cutoff value for "normal" PAWP response to exercise in individuals >40 years old.
Original language | English |
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Journal | Journal of Cardiac Failure |
Volume | 25 |
Issue number | 2 |
Pages (from-to) | 114-122 |
ISSN | 1071-9164 |
DOIs | |
Publication status | Published - Feb 2019 |
- Adult, Cardiac Catheterization, Exercise/physiology, Healthy Volunteers, Heart Failure/physiopathology, Humans, Pulmonary Wedge Pressure/physiology, Rest/physiology, Stroke Volume/physiology
Research areas
ID: 235153129