Protein feature based identification of cell cycle regulated proteins in yeast
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Protein feature based identification of cell cycle regulated proteins in yeast. / de Lichtenberg, Ulrik; Jensen, Thomas S; Jensen, Lars J; Brunak, Søren.
In: Journal of Molecular Biology, Vol. 329, No. 4, 2003, p. 663-74.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Protein feature based identification of cell cycle regulated proteins in yeast
AU - de Lichtenberg, Ulrik
AU - Jensen, Thomas S
AU - Jensen, Lars J
AU - Brunak, Søren
PY - 2003
Y1 - 2003
N2 - DNA microarrays have been used extensively to identify cell cycle regulated genes in yeast; however, the overlap in the genes identified is surprisingly small. We show that certain protein features can be used to distinguish cell cycle regulated genes from other genes with high confidence (features include protein phosphorylation, glycosylation, subcellular location and instability/degradation). We demonstrate that co-expressed, periodic genes encode proteins which share combinations of features, and provide an overview of the proteome dynamics during the cycle. A large set of novel putative cell cycle regulated proteins were identified, many of which have no known function.
AB - DNA microarrays have been used extensively to identify cell cycle regulated genes in yeast; however, the overlap in the genes identified is surprisingly small. We show that certain protein features can be used to distinguish cell cycle regulated genes from other genes with high confidence (features include protein phosphorylation, glycosylation, subcellular location and instability/degradation). We demonstrate that co-expressed, periodic genes encode proteins which share combinations of features, and provide an overview of the proteome dynamics during the cycle. A large set of novel putative cell cycle regulated proteins were identified, many of which have no known function.
M3 - Journal article
VL - 329
SP - 663
EP - 674
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 4
ER -
ID: 46457265