Probing cellular health at the muscle level—Multi-frequency bioimpedance in Parkinson's disease
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Probing cellular health at the muscle level—Multi-frequency bioimpedance in Parkinson's disease. / Celicanin, Marko; Harrison, Adrian Paul; Olsen, Jack Kvistgaard; Korbo, Lise; Løkkegård, Annemette; Petersen, Charlotte Bjerg; Danneskiold-Samsøe, Bente; Siebner, Hartwig Roman; Ilic, Tihomir; Bartels, Else Marie.
In: Physiological Reports, Vol. 10, No. 19, e15465, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Probing cellular health at the muscle level—Multi-frequency bioimpedance in Parkinson's disease
AU - Celicanin, Marko
AU - Harrison, Adrian Paul
AU - Olsen, Jack Kvistgaard
AU - Korbo, Lise
AU - Løkkegård, Annemette
AU - Petersen, Charlotte Bjerg
AU - Danneskiold-Samsøe, Bente
AU - Siebner, Hartwig Roman
AU - Ilic, Tihomir
AU - Bartels, Else Marie
N1 - Publisher Copyright: © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
PY - 2022
Y1 - 2022
N2 - Bioimpedance (mfBIA) non-invasively assesses cellular muscle health. Our aim was to explore whether mfBIA captures abnormal cellular muscle health in patients with Parkinson's Disease (PD) and how such changes are modulated with the use of Parkinson's medication. In patients with PD (n = 20) mfBIA measurements were made of biceps brachii, triceps, and extensor carpi radialis longus muscles of the more affected arm whilst at rest, using a mobile mfBIA device (IMPEDIMED, Australia). mfBIA and assessment of motor symptoms were performed in a pragmatic off-medication state, as well as one and 3 h after oral intake of 200 mg levodopa. Age and sex-matched healthy subjects (HC; n = 20) served as controls. PD and HC mfBIA parameters were compared by applying an unpaired two-tailed adjusted t-test and ANOVA with Tukey's correction for multiple comparisons (p ≤ 0.05). The PD group consisted of 13 men (71 ± 17 years) and 7 women (65 ± 7 years). Independent of medication, internal (Ri) and external resistance (Re) were found to be significantly higher, and membrane capacitance (Mc) significantly lower, in m.biceps brachii in PD subjects compared to HC. Center frequency (fc) was significantly higher in m.biceps brachii of PD subjects in the “medication-off” state. There was no difference between PD and HC in mfBIA parameters in the measured extensor muscles. The upper limb flexor muscle shows a difference in mfBIA parameters in PD compared to HC. mfBIA may be useful in the diagnosis and assessment of PD patients and is objective, non-invasive, reliable, and easy to use.
AB - Bioimpedance (mfBIA) non-invasively assesses cellular muscle health. Our aim was to explore whether mfBIA captures abnormal cellular muscle health in patients with Parkinson's Disease (PD) and how such changes are modulated with the use of Parkinson's medication. In patients with PD (n = 20) mfBIA measurements were made of biceps brachii, triceps, and extensor carpi radialis longus muscles of the more affected arm whilst at rest, using a mobile mfBIA device (IMPEDIMED, Australia). mfBIA and assessment of motor symptoms were performed in a pragmatic off-medication state, as well as one and 3 h after oral intake of 200 mg levodopa. Age and sex-matched healthy subjects (HC; n = 20) served as controls. PD and HC mfBIA parameters were compared by applying an unpaired two-tailed adjusted t-test and ANOVA with Tukey's correction for multiple comparisons (p ≤ 0.05). The PD group consisted of 13 men (71 ± 17 years) and 7 women (65 ± 7 years). Independent of medication, internal (Ri) and external resistance (Re) were found to be significantly higher, and membrane capacitance (Mc) significantly lower, in m.biceps brachii in PD subjects compared to HC. Center frequency (fc) was significantly higher in m.biceps brachii of PD subjects in the “medication-off” state. There was no difference between PD and HC in mfBIA parameters in the measured extensor muscles. The upper limb flexor muscle shows a difference in mfBIA parameters in PD compared to HC. mfBIA may be useful in the diagnosis and assessment of PD patients and is objective, non-invasive, reliable, and easy to use.
KW - bioimpedance
KW - multi-frequency
KW - muscle tonus
KW - muscles
KW - Parkinson's disease
U2 - 10.14814/phy2.15465
DO - 10.14814/phy2.15465
M3 - Journal article
C2 - 36200221
AN - SCOPUS:85139352469
VL - 10
JO - Physiological Reports
JF - Physiological Reports
SN - 2051-817X
IS - 19
M1 - e15465
ER -
ID: 326025316