Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease

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Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease. / Omann, Camilla; Nyboe, Camilla; Kristensen, Rasmus; Ernst, Andreas; Ramlau-Hansen, Cecilia Høst; Rask, Charlotte; Tabor, Ann; Gaynor, J. William; Hjortdal, Vibeke E.

In: European Heart Journal Open, Vol. 2, No. 3, oeac027, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Omann, C, Nyboe, C, Kristensen, R, Ernst, A, Ramlau-Hansen, CH, Rask, C, Tabor, A, Gaynor, JW & Hjortdal, VE 2022, 'Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease', European Heart Journal Open, vol. 2, no. 3, oeac027. https://doi.org/10.1093/ehjopen/oeac027

APA

Omann, C., Nyboe, C., Kristensen, R., Ernst, A., Ramlau-Hansen, C. H., Rask, C., Tabor, A., Gaynor, J. W., & Hjortdal, V. E. (2022). Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease. European Heart Journal Open, 2(3), [oeac027]. https://doi.org/10.1093/ehjopen/oeac027

Vancouver

Omann C, Nyboe C, Kristensen R, Ernst A, Ramlau-Hansen CH, Rask C et al. Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease. European Heart Journal Open. 2022;2(3). oeac027. https://doi.org/10.1093/ehjopen/oeac027

Author

Omann, Camilla ; Nyboe, Camilla ; Kristensen, Rasmus ; Ernst, Andreas ; Ramlau-Hansen, Cecilia Høst ; Rask, Charlotte ; Tabor, Ann ; Gaynor, J. William ; Hjortdal, Vibeke E. / Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease. In: European Heart Journal Open. 2022 ; Vol. 2, No. 3.

Bibtex

@article{c1ae0272294345a9a481c33d4d63291d,

title = "Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease",

abstract = "AIMS: Our primary aim was to examine whether exposure to pre-eclampsia increases the risk of neurodevelopmental disorders in children born with congenital heart disease (CHD). Our secondary aim was to evaluate whether CHD and pre-eclampsia may act in synergy and potentiate this risk.METHOD AND RESULTS: Using population-based registries, we included all Danish children born with CHD between 1994 and 2017. Non-singletons and children born with a syndrome were excluded. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder, autism spectrum disorders, and tic disorders were identified with the use of the 10th edition of International Classification of Disease (ICD-10) codes DF80-DF98. Using Cox proportional hazard regression, we estimated the risk of neurodevelopmental disorders in children with CHD exposed to pre-eclampsia compared with those with CHD not exposed to pre-eclampsia. The population consisted of 11 449 children born with CHD. Children exposed to pre-eclampsia had an increased risk of neurodevelopmental disorders, hazard ratio: 1.84 (95% confidence interval: 1.39-2.42). Furthermore, a comparison cohort of 113 713 children with no CHD diagnoses were included. Using cumulative incidence analyses with death as competing risk, we compared the risk of neurodevelopmental disorders if exposed to pre-eclampsia among children with CHD and children without CHD. Exposure to pre-eclampsia drastically increased the cumulative incidence of neurodevelopmental disorders in children born with CHD.CONCLUSION: Exposure to pre-eclampsia is associated with increased risk of neurodevelopmental disorders in children born with CHD. CHD and pre-eclampsia may act in synergy and potentiate this effect. Clinicians should therefore be especially attentive to neurodevelopmental problems in this vulnerable subgroup.",

author = "Camilla Omann and Camilla Nyboe and Rasmus Kristensen and Andreas Ernst and Ramlau-Hansen, {Cecilia H{\o}st} and Charlotte Rask and Ann Tabor and Gaynor, {J. William} and Hjortdal, {Vibeke E.}",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.",

year = "2022",

doi = "10.1093/ehjopen/oeac027",

language = "English",

volume = "2",

journal = "European Heart Journal Open",

issn = "2752-4191",

publisher = "Oxford University Press",

number = "3",

}

RIS

TY - JOUR

T1 - Pre-eclampsia is associated with increased neurodevelopmental disorders in children with congenital heart disease

AU - Omann, Camilla

AU - Nyboe, Camilla

AU - Kristensen, Rasmus

AU - Ernst, Andreas

AU - Ramlau-Hansen, Cecilia Høst

AU - Rask, Charlotte

AU - Tabor, Ann

AU - Gaynor, J. William

AU - Hjortdal, Vibeke E.

PY - 2022

Y1 - 2022

N2 - AIMS: Our primary aim was to examine whether exposure to pre-eclampsia increases the risk of neurodevelopmental disorders in children born with congenital heart disease (CHD). Our secondary aim was to evaluate whether CHD and pre-eclampsia may act in synergy and potentiate this risk.METHOD AND RESULTS: Using population-based registries, we included all Danish children born with CHD between 1994 and 2017. Non-singletons and children born with a syndrome were excluded. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder, autism spectrum disorders, and tic disorders were identified with the use of the 10th edition of International Classification of Disease (ICD-10) codes DF80-DF98. Using Cox proportional hazard regression, we estimated the risk of neurodevelopmental disorders in children with CHD exposed to pre-eclampsia compared with those with CHD not exposed to pre-eclampsia. The population consisted of 11 449 children born with CHD. Children exposed to pre-eclampsia had an increased risk of neurodevelopmental disorders, hazard ratio: 1.84 (95% confidence interval: 1.39-2.42). Furthermore, a comparison cohort of 113 713 children with no CHD diagnoses were included. Using cumulative incidence analyses with death as competing risk, we compared the risk of neurodevelopmental disorders if exposed to pre-eclampsia among children with CHD and children without CHD. Exposure to pre-eclampsia drastically increased the cumulative incidence of neurodevelopmental disorders in children born with CHD.CONCLUSION: Exposure to pre-eclampsia is associated with increased risk of neurodevelopmental disorders in children born with CHD. CHD and pre-eclampsia may act in synergy and potentiate this effect. Clinicians should therefore be especially attentive to neurodevelopmental problems in this vulnerable subgroup.

AB - AIMS: Our primary aim was to examine whether exposure to pre-eclampsia increases the risk of neurodevelopmental disorders in children born with congenital heart disease (CHD). Our secondary aim was to evaluate whether CHD and pre-eclampsia may act in synergy and potentiate this risk.METHOD AND RESULTS: Using population-based registries, we included all Danish children born with CHD between 1994 and 2017. Non-singletons and children born with a syndrome were excluded. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder, autism spectrum disorders, and tic disorders were identified with the use of the 10th edition of International Classification of Disease (ICD-10) codes DF80-DF98. Using Cox proportional hazard regression, we estimated the risk of neurodevelopmental disorders in children with CHD exposed to pre-eclampsia compared with those with CHD not exposed to pre-eclampsia. The population consisted of 11 449 children born with CHD. Children exposed to pre-eclampsia had an increased risk of neurodevelopmental disorders, hazard ratio: 1.84 (95% confidence interval: 1.39-2.42). Furthermore, a comparison cohort of 113 713 children with no CHD diagnoses were included. Using cumulative incidence analyses with death as competing risk, we compared the risk of neurodevelopmental disorders if exposed to pre-eclampsia among children with CHD and children without CHD. Exposure to pre-eclampsia drastically increased the cumulative incidence of neurodevelopmental disorders in children born with CHD.CONCLUSION: Exposure to pre-eclampsia is associated with increased risk of neurodevelopmental disorders in children born with CHD. CHD and pre-eclampsia may act in synergy and potentiate this effect. Clinicians should therefore be especially attentive to neurodevelopmental problems in this vulnerable subgroup.

U2 - 10.1093/ehjopen/oeac027

DO - 10.1093/ehjopen/oeac027

M3 - Journal article

C2 - 35919351

VL - 2

JO - European Heart Journal Open

JF - European Heart Journal Open

SN - 2752-4191

IS - 3

M1 - oeac027

ER -

ID: 346062141