Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography
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Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography. / Jespersen, Lasse; Abildstrøm, Steen Z; Peña, Adam; Hansen, Peter R; Prescott, Eva.
In: Clinical Research in Cardiology, Vol. 103, No. 5, 2014, p. 381-387.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Predictive value of the corrected TIMI frame count in patients with suspected angina pectoris but no obstructive coronary artery disease at angiography
AU - Jespersen, Lasse
AU - Abildstrøm, Steen Z
AU - Peña, Adam
AU - Hansen, Peter R
AU - Prescott, Eva
PY - 2014
Y1 - 2014
N2 - AIMS: To evaluate whether the corrected thrombolysis in myocardial infarction frame count (CTFC), an index of resting coronary blood flow, is associated with the risk of major adverse cardiovascular events (MACE) in patients with suspected stable angina pectoris (SAP) but no obstructive coronary artery disease (CAD) at angiography.METHODS AND RESULTS: In this case-control study, CTFC at baseline in 127 patients (50 % women) who subsequently experienced a myocardial infarction, non-hemorrhagic stroke or cardiovascular death during 2001-2011 was compared with CTFC in 254 event-free matched controls. All patients had suspected SAP but no obstructive (≥50 % stenosis) CAD at baseline angiography. Mean CTFC in controls was 23.4 (95 % confidence interval 20.9-25.9) frames and mean CTFC in cases did not differ significantly with a difference of -1.0 (-3.1 to 1.1) frames (P = 0.35) and no sex-specific interaction (P = 0.18). In a conditional logistic regression model, we found no dose-response relationship between CTFC and the risk of MACE, i.e., compared to the risk in the lowest CTFC quintile, the odds ratios for MACE were 1.3 (0.7-2.6), 0.7 (0.3-1.3), 0.7 (0.4-1.5) and 1.0 (0.5-2.1) in the second, third, fourth and fifth CTFC quintiles, respectively. Adjustment for cardiac risk factors including diabetes, active smoking, body mass index, and use of lipid-lowering and antihypertensive medication did not significantly change the results.CONCLUSIONS: In patients with SAP symptoms without obstructive CAD at angiography, CTFC is not associated with the risk of MACE.
AB - AIMS: To evaluate whether the corrected thrombolysis in myocardial infarction frame count (CTFC), an index of resting coronary blood flow, is associated with the risk of major adverse cardiovascular events (MACE) in patients with suspected stable angina pectoris (SAP) but no obstructive coronary artery disease (CAD) at angiography.METHODS AND RESULTS: In this case-control study, CTFC at baseline in 127 patients (50 % women) who subsequently experienced a myocardial infarction, non-hemorrhagic stroke or cardiovascular death during 2001-2011 was compared with CTFC in 254 event-free matched controls. All patients had suspected SAP but no obstructive (≥50 % stenosis) CAD at baseline angiography. Mean CTFC in controls was 23.4 (95 % confidence interval 20.9-25.9) frames and mean CTFC in cases did not differ significantly with a difference of -1.0 (-3.1 to 1.1) frames (P = 0.35) and no sex-specific interaction (P = 0.18). In a conditional logistic regression model, we found no dose-response relationship between CTFC and the risk of MACE, i.e., compared to the risk in the lowest CTFC quintile, the odds ratios for MACE were 1.3 (0.7-2.6), 0.7 (0.3-1.3), 0.7 (0.4-1.5) and 1.0 (0.5-2.1) in the second, third, fourth and fifth CTFC quintiles, respectively. Adjustment for cardiac risk factors including diabetes, active smoking, body mass index, and use of lipid-lowering and antihypertensive medication did not significantly change the results.CONCLUSIONS: In patients with SAP symptoms without obstructive CAD at angiography, CTFC is not associated with the risk of MACE.
KW - Aged
KW - Angina Pectoris
KW - Blood Flow Velocity
KW - Case-Control Studies
KW - Comorbidity
KW - Confidence Intervals
KW - Coronary Angiography
KW - Coronary Circulation
KW - Coronary Thrombosis
KW - Denmark
KW - Diagnosis, Differential
KW - Female
KW - Humans
KW - Kaplan-Meier Estimate
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Myocardial Infarction
KW - Predictive Value of Tests
KW - Regional Blood Flow
KW - Retrospective Studies
KW - Risk Assessment
KW - Survival Rate
KW - Thrombolytic Therapy
KW - Vascular Patency
U2 - 10.1007/s00392-014-0665-7
DO - 10.1007/s00392-014-0665-7
M3 - Journal article
C2 - 24442337
VL - 103
SP - 381
EP - 387
JO - Clinical Research in Cardiology
JF - Clinical Research in Cardiology
SN - 1861-0684
IS - 5
ER -
ID: 138172981