Powder diffractometric assay of two polymorphic forms of ranitidine hydrochloride
Research output: Contribution to journal › Journal article › Research › peer-review
A simple X-ray powder diffractometric method was developed for the qualitative and quantitative assay of the two crystalline modifications of ranitidine-HCl. The main purpose of the present work was to investigate if artificial neural networks (ANNs) could be applied in quantitative X-ray diffractometric analyses. The ANN approach was compared with a conventional mixture design method. The results obtained by the ANN had a smaller standard deviation and relative error and a better precision at lower concentrations. ANNs provide a simple alternative to conventional statistical modelling methods to identify the non-linear relationship without complex equations. Copyright (C) 1999 Elsevier Science B.V.
Original language | English |
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Journal | International Journal of Pharmaceutics |
Volume | 184 |
Issue number | 1 |
Pages (from-to) | 107-114 |
Number of pages | 8 |
ISSN | 0378-5173 |
DOIs | |
Publication status | Published - 5 Jul 1999 |
- Artificial neural network, Polymorphism, Ranitidine hydrochloride, X-ray powder diffraction
Research areas
ID: 399071884