Pharmacokinetics of 6-Thioguanine and 6-Mercaptopurine Combination Maintenance Therapy of Childhood ALL: Hypothesis and Case Report
Research output: Contribution to journal › Journal article › Research › peer-review
Methotrexate/6-mercaptopurine maintenance therapy of childhood acute lymphoblastic leukemia is challenged by treatment-related hepatotoxicity, failure to achieve the myelosuppressive target, and lack of direct parameters for monitoring treatment efficacy or even intensity. Patients with low thiopurine methyltransferase (TPMT) activity have lower levels of hepatotoxic methylated thiopurine metabolites (MeMPs), higher levels of thioguanine nucleotides (TGNs), and reduced relapse rates. Addition of 6-thioguanine to maintenance therapy of a child with ALL and high TPMT activity increased the TGN/MeMP index in erythrocytes 5.5-fold, mimicking the more favorable thiopurine metabolism seen in patients with low TPMT activity.
Original language | English |
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Journal | Journal of Pediatric Hematology/Oncology |
Volume | 37 |
Issue number | 3 |
Pages (from-to) | e206-e209 |
Number of pages | 4 |
ISSN | 1077-4114 |
DOIs | |
Publication status | Published - Apr 2015 |
- 6-Mercaptopurine, Antimetabolites, Antineoplastic, Child, Erythrocytes, Female, Humans, Methyltransferases, Neoplasm Recurrence, Local, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Remission Induction, Thioguanine
Research areas
ID: 152269273