Personalized exercise intervention in HPN patients - A feasibility study
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Personalized exercise intervention in HPN patients - A feasibility study. / Graungaard, Signe; Geisler, Lea; Andersen, Jens Rikardt; Rasmussen, Henrik Højgaard; Vinter-Jensen, Lars; Holst, Mette.
In: Clinical Nutrition ESPEN, Vol. 45, 2021, p. 420-425.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Personalized exercise intervention in HPN patients - A feasibility study
AU - Graungaard, Signe
AU - Geisler, Lea
AU - Andersen, Jens Rikardt
AU - Rasmussen, Henrik Højgaard
AU - Vinter-Jensen, Lars
AU - Holst, Mette
N1 - Publisher Copyright: © 2021 The Authors
PY - 2021
Y1 - 2021
N2 - Background: Physical health status may be predictive of readmissions, psychological health and mortality in patients with short bowel syndrome. Aims: This study aimed to investigate the feasibility and effect of an individualized exercise intervention and secondary, oral nutrition intake counseling on Timed-Up-and-Go (TUG) and 30 s Chair Stand Test (CST) as well as body-composition and EuroQol (EQ)-5D-5L, in patients with chronic intestinal failure (IF) type III receiving HPN and/or fluid therapy. Methods: A 12-week individualized exercise intervention consisting on three weekly home based sessions, and nutrition counselling focusing on protein intake and reducing high stoma output, was performed. Weekly follow-up by phone was done on motivation to exercise. Results: The study invited 71 patients, 44 accepted the invitation (62%), 37(52%) were included, and 31 (84%) completed the intervention. The exercise intervention was well tolerated. TUG improved from 8.9(SD 5.5) to 7.7(SD 3.8) (p = 0.033). CST improved by four repetitions (<0.001∗). A statistical, however not clinically relevant improvement was seen in muscle mass. No improvement was seen in (EQ)-5D-5L total, but insignificantly (p = 0.055) for physical function only. Protein intake improved by 10.6 g/day (p = 0.008). Conclusions: A 12 weeks individualized exercise intervention showed very feasible and beneficial in HPN patients. Physical function improved statistically and clinically, and oral protein intake improved. QoL overall did not improve, however COVID-19 was an uninvited partner throughout the study period, which may have influenced general QoL. As only 62% accepted the invitation to participate, home based exercise intervention may not apply to all patients.
AB - Background: Physical health status may be predictive of readmissions, psychological health and mortality in patients with short bowel syndrome. Aims: This study aimed to investigate the feasibility and effect of an individualized exercise intervention and secondary, oral nutrition intake counseling on Timed-Up-and-Go (TUG) and 30 s Chair Stand Test (CST) as well as body-composition and EuroQol (EQ)-5D-5L, in patients with chronic intestinal failure (IF) type III receiving HPN and/or fluid therapy. Methods: A 12-week individualized exercise intervention consisting on three weekly home based sessions, and nutrition counselling focusing on protein intake and reducing high stoma output, was performed. Weekly follow-up by phone was done on motivation to exercise. Results: The study invited 71 patients, 44 accepted the invitation (62%), 37(52%) were included, and 31 (84%) completed the intervention. The exercise intervention was well tolerated. TUG improved from 8.9(SD 5.5) to 7.7(SD 3.8) (p = 0.033). CST improved by four repetitions (<0.001∗). A statistical, however not clinically relevant improvement was seen in muscle mass. No improvement was seen in (EQ)-5D-5L total, but insignificantly (p = 0.055) for physical function only. Protein intake improved by 10.6 g/day (p = 0.008). Conclusions: A 12 weeks individualized exercise intervention showed very feasible and beneficial in HPN patients. Physical function improved statistically and clinically, and oral protein intake improved. QoL overall did not improve, however COVID-19 was an uninvited partner throughout the study period, which may have influenced general QoL. As only 62% accepted the invitation to participate, home based exercise intervention may not apply to all patients.
KW - Home parenteral nutrition
KW - Intestinal failure
KW - Physical exercise
KW - Prevention
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85112512837&partnerID=8YFLogxK
U2 - 10.1016/j.clnesp.2021.07.008
DO - 10.1016/j.clnesp.2021.07.008
M3 - Journal article
C2 - 34620349
AN - SCOPUS:85112512837
VL - 45
SP - 420
EP - 425
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
SN - 2405-4577
ER -
ID: 276850750