Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients. / Nielsen, Dorthe Viemose; Hjortdal, Vibeke; Larsson, Heidi; Johnsen, Søren Påske; Jakobsen, Carl-Johan.

In: The Journal of Thoracic and Cardiovascular Surgery, Vol. 142, No. 3, 2011, p. 656-661.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, DV, Hjortdal, V, Larsson, H, Johnsen, SP & Jakobsen, C-J 2011, 'Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients', The Journal of Thoracic and Cardiovascular Surgery, vol. 142, no. 3, pp. 656-661. https://doi.org/10.1016/j.jtcvs.2011.03.019

APA

Nielsen, D. V., Hjortdal, V., Larsson, H., Johnsen, S. P., & Jakobsen, C-J. (2011). Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients. The Journal of Thoracic and Cardiovascular Surgery, 142(3), 656-661. https://doi.org/10.1016/j.jtcvs.2011.03.019

Vancouver

Nielsen DV, Hjortdal V, Larsson H, Johnsen SP, Jakobsen C-J. Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients. The Journal of Thoracic and Cardiovascular Surgery. 2011;142(3):656-661. https://doi.org/10.1016/j.jtcvs.2011.03.019

Author

Nielsen, Dorthe Viemose ; Hjortdal, Vibeke ; Larsson, Heidi ; Johnsen, Søren Påske ; Jakobsen, Carl-Johan. / Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients. In: The Journal of Thoracic and Cardiovascular Surgery. 2011 ; Vol. 142, No. 3. pp. 656-661.

Bibtex

@article{ba213e4d07884d89b4af30609861f095,
title = "Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients",
abstract = "BACKGROUND: Aminoglycoside treatment has been associated with nephrotoxic effects. However, the effect of perioperative aminoglycoside treatment on the risk of acute kidney injury requiring dialysis among patients undergoing cardiac surgery remains uncertain.METHODS: We performed a register study based on prospectively collected data from population-based health care databases of 3625 consecutive patients undergoing cardiac surgery at the Aarhus University Hospital, Skejby, Denmark. Patients requiring preoperative dialysis were excluded, leaving a total of 3587 patients (99% of original patient cohort), of whom 89 received perioperative aminoglycosides.RESULTS: The cumulative risk of in-hospital dialysis-dependent acute kidney injury was 3.2% (n = 115). Perioperative use of aminoglycosides was associated with an increased risk of postoperative dialysis (adjusted odds ratio [OR], 4.41; 95% confidence interval [CI], 1.83-10.59). Other predictors included reoperation because of bleeding (adjusted OR, 2.80; 95% CI, 1.63-4.80), use of inotropic support during anesthesia (adjusted OR, 2.10; 95% confidence interval, 1.49-2.95), and cardiopulmonary bypass lasting longer than 120 minutes (adjusted OR, 1.95; 95% CI, 1.19-3.20) along with EuroSCORE variables. Postoperative dialysis was associated with higher 30-day mortality (10.9% vs 2.5%, P < .0001, χ(2) test), but use of aminoglycosides was not independently associated with mortality.CONCLUSIONS: Perioperative use of aminoglycosides in adults undergoing cardiac surgery was associated with increased risk of postoperative dialysis.",
keywords = "Acute Kidney Injury/chemically induced, Adult, Aged, Aminoglycosides/adverse effects, Cardiac Surgical Procedures, Female, Hospital Mortality, Humans, Kidney/drug effects, Male, Middle Aged, Perioperative Period, Postoperative Complications/chemically induced, Renal Dialysis/statistics & numerical data",
author = "Nielsen, {Dorthe Viemose} and Vibeke Hjortdal and Heidi Larsson and Johnsen, {S{\o}ren P{\aa}ske} and Carl-Johan Jakobsen",
note = "Copyright {\textcopyright} 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.",
year = "2011",
doi = "10.1016/j.jtcvs.2011.03.019",
language = "English",
volume = "142",
pages = "656--661",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Perioperative aminoglycoside treatment is associated with a higher incidence of postoperative dialysis in adult cardiac surgery patients

AU - Nielsen, Dorthe Viemose

AU - Hjortdal, Vibeke

AU - Larsson, Heidi

AU - Johnsen, Søren Påske

AU - Jakobsen, Carl-Johan

N1 - Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Aminoglycoside treatment has been associated with nephrotoxic effects. However, the effect of perioperative aminoglycoside treatment on the risk of acute kidney injury requiring dialysis among patients undergoing cardiac surgery remains uncertain.METHODS: We performed a register study based on prospectively collected data from population-based health care databases of 3625 consecutive patients undergoing cardiac surgery at the Aarhus University Hospital, Skejby, Denmark. Patients requiring preoperative dialysis were excluded, leaving a total of 3587 patients (99% of original patient cohort), of whom 89 received perioperative aminoglycosides.RESULTS: The cumulative risk of in-hospital dialysis-dependent acute kidney injury was 3.2% (n = 115). Perioperative use of aminoglycosides was associated with an increased risk of postoperative dialysis (adjusted odds ratio [OR], 4.41; 95% confidence interval [CI], 1.83-10.59). Other predictors included reoperation because of bleeding (adjusted OR, 2.80; 95% CI, 1.63-4.80), use of inotropic support during anesthesia (adjusted OR, 2.10; 95% confidence interval, 1.49-2.95), and cardiopulmonary bypass lasting longer than 120 minutes (adjusted OR, 1.95; 95% CI, 1.19-3.20) along with EuroSCORE variables. Postoperative dialysis was associated with higher 30-day mortality (10.9% vs 2.5%, P < .0001, χ(2) test), but use of aminoglycosides was not independently associated with mortality.CONCLUSIONS: Perioperative use of aminoglycosides in adults undergoing cardiac surgery was associated with increased risk of postoperative dialysis.

AB - BACKGROUND: Aminoglycoside treatment has been associated with nephrotoxic effects. However, the effect of perioperative aminoglycoside treatment on the risk of acute kidney injury requiring dialysis among patients undergoing cardiac surgery remains uncertain.METHODS: We performed a register study based on prospectively collected data from population-based health care databases of 3625 consecutive patients undergoing cardiac surgery at the Aarhus University Hospital, Skejby, Denmark. Patients requiring preoperative dialysis were excluded, leaving a total of 3587 patients (99% of original patient cohort), of whom 89 received perioperative aminoglycosides.RESULTS: The cumulative risk of in-hospital dialysis-dependent acute kidney injury was 3.2% (n = 115). Perioperative use of aminoglycosides was associated with an increased risk of postoperative dialysis (adjusted odds ratio [OR], 4.41; 95% confidence interval [CI], 1.83-10.59). Other predictors included reoperation because of bleeding (adjusted OR, 2.80; 95% CI, 1.63-4.80), use of inotropic support during anesthesia (adjusted OR, 2.10; 95% confidence interval, 1.49-2.95), and cardiopulmonary bypass lasting longer than 120 minutes (adjusted OR, 1.95; 95% CI, 1.19-3.20) along with EuroSCORE variables. Postoperative dialysis was associated with higher 30-day mortality (10.9% vs 2.5%, P < .0001, χ(2) test), but use of aminoglycosides was not independently associated with mortality.CONCLUSIONS: Perioperative use of aminoglycosides in adults undergoing cardiac surgery was associated with increased risk of postoperative dialysis.

KW - Acute Kidney Injury/chemically induced

KW - Adult

KW - Aged

KW - Aminoglycosides/adverse effects

KW - Cardiac Surgical Procedures

KW - Female

KW - Hospital Mortality

KW - Humans

KW - Kidney/drug effects

KW - Male

KW - Middle Aged

KW - Perioperative Period

KW - Postoperative Complications/chemically induced

KW - Renal Dialysis/statistics & numerical data

U2 - 10.1016/j.jtcvs.2011.03.019

DO - 10.1016/j.jtcvs.2011.03.019

M3 - Journal article

C2 - 21524425

VL - 142

SP - 656

EP - 661

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 3

ER -

ID: 247872727