Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes
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Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes. / Madsen, Jakob Torp; Vogel, Stefan; Johansen, Jeanne Duus; Sørensen, Jens Ahm; Andersen, Klaus Ejner; Nielsen, Jesper Bo.
In: Cutaneous and Ocular Toxicology, Vol. 30, No. 1, 01.03.2011, p. 38-44.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes
AU - Madsen, Jakob Torp
AU - Vogel, Stefan
AU - Johansen, Jeanne Duus
AU - Sørensen, Jens Ahm
AU - Andersen, Klaus Ejner
AU - Nielsen, Jesper Bo
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.
AB - Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.
U2 - http://dx.doi.org/10.3109/15569527.2010.521220
DO - http://dx.doi.org/10.3109/15569527.2010.521220
M3 - Journal article
VL - 30
SP - 38
EP - 44
JO - Cutaneous and Ocular Toxicology
JF - Cutaneous and Ocular Toxicology
SN - 1556-9527
IS - 1
ER -
ID: 40166298