Percutaneous atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: a systematic review
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This review aims to evaluate systematically the safety and efficacy of percutaneous left atrial appendage occlusion (PLAAO) in stroke prevention for patients with atrial fibrillation (AF). A systematic review of peer-reviewed journals on PLAAO before June 2011 was performed on three electronic databases. Fourteen studies were identified for evaluation. Overall, implantation was successful in 93% of all cases. Periprocedural mortality and stroke rates were 1.1% and 0.6%, respectively. The incidences of pericardial effusion/cardiac tamponade and device embolisation were 4% and 0.7%, respectively. At the time of the latest follow-up (up to 40 months), the overall incidence of stroke among all studies was 1.4% per annum. Existing evidence suggests that PLAAO is a relatively safe treatment for patients with AF. However, there is a need for further evaluation of its efficacy in the form of large and well-designed randomised controlled trials.
Original language | English |
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Journal | Heart |
Volume | 98 |
Issue number | 12 |
Pages (from-to) | 900-7 |
Number of pages | 8 |
ISSN | 1355-6037 |
DOIs | |
Publication status | Published - 2012 |
ID: 48439524