Pattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database
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Pattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database. / Clemmensen, Kim Katrine Bjerring; Thomsen, Simon Francis; Jemec, Gregor Borut Ernst; Agner, Tove.
In: Contact Dermatitis, Vol. 71, No. 2, 08.2014, p. 75-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database
AU - Clemmensen, Kim Katrine Bjerring
AU - Thomsen, Simon Francis
AU - Jemec, Gregor Borut Ernst
AU - Agner, Tove
N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2014/8
Y1 - 2014/8
N2 - BACKGROUND: Both atopic dermatitis and contact sensitization are common conditions; however, a definite understanding of the relationship between contact sensitization and atopic dermatitis has not been reached.OBJECTIVES: In this descriptive study, we investigated the differences between positive patch test reactions in patients with and without atopic dermatitis in a patch test cohort, and explored the influence of disease severity.PATIENTS/MATERIALS/METHODS: Patch test results, information on atopic dermatitis and demographic variables were taken from a database, including all patients patch tested at Bispebjerg and Roskilde Hospitals from January 2009 to January 2013. Severe atopic dermatitis was defined as systemic therapy or hospitalization resulting from atopic dermatitis. All other patients with atopic dermatitis were defined as having mild/moderate disease.RESULTS: The study included 2221 patients: 293 patients with atopic dermatitis and 1928 without. Forty-one per cent of patients with and 46.2% of patients without atopic dermatitis had at least one positive patch test reaction (p = 0.092). More patients with severe atopic dermatitis than patients with non-severe atopic dermatitis had multiple positive patch test reactions (19.4% versus 10.0%, p = 0.046).CONCLUSIONS: Overall, we found similar frequencies of positive patch test reactions in patients with and without atopic dermatitis. However, a higher frequency of multiple sensitizations was found in patients with severe atopic dermatitis.
AB - BACKGROUND: Both atopic dermatitis and contact sensitization are common conditions; however, a definite understanding of the relationship between contact sensitization and atopic dermatitis has not been reached.OBJECTIVES: In this descriptive study, we investigated the differences between positive patch test reactions in patients with and without atopic dermatitis in a patch test cohort, and explored the influence of disease severity.PATIENTS/MATERIALS/METHODS: Patch test results, information on atopic dermatitis and demographic variables were taken from a database, including all patients patch tested at Bispebjerg and Roskilde Hospitals from January 2009 to January 2013. Severe atopic dermatitis was defined as systemic therapy or hospitalization resulting from atopic dermatitis. All other patients with atopic dermatitis were defined as having mild/moderate disease.RESULTS: The study included 2221 patients: 293 patients with atopic dermatitis and 1928 without. Forty-one per cent of patients with and 46.2% of patients without atopic dermatitis had at least one positive patch test reaction (p = 0.092). More patients with severe atopic dermatitis than patients with non-severe atopic dermatitis had multiple positive patch test reactions (19.4% versus 10.0%, p = 0.046).CONCLUSIONS: Overall, we found similar frequencies of positive patch test reactions in patients with and without atopic dermatitis. However, a higher frequency of multiple sensitizations was found in patients with severe atopic dermatitis.
KW - Adult
KW - Allergens
KW - Databases as Topic
KW - Denmark
KW - Dermatitis, Allergic Contact
KW - Dermatitis, Atopic
KW - Dermatitis, Occupational
KW - Facial Dermatoses
KW - Female
KW - Hand Dermatoses
KW - Hospitals
KW - Humans
KW - Leg Dermatoses
KW - Male
KW - Patch Tests
KW - Severity of Illness Index
U2 - 10.1111/cod.12229
DO - 10.1111/cod.12229
M3 - Journal article
C2 - 24697272
VL - 71
SP - 75
EP - 81
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 2
ER -
ID: 135492025