Organoids as regenerative medicine for inflammatory bowel disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Organoids as regenerative medicine for inflammatory bowel disease. / Hammerhøj, Alexander; Chakravarti, Deepavali; Sato, Toshiro; Jensen, Kim Bak; Nielsen, Ole Haagen.

In: iScience, Vol. 27, No. 6, 110118, 2024.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hammerhøj, A, Chakravarti, D, Sato, T, Jensen, KB & Nielsen, OH 2024, 'Organoids as regenerative medicine for inflammatory bowel disease', iScience, vol. 27, no. 6, 110118. https://doi.org/10.1016/j.isci.2024.110118

APA

Hammerhøj, A., Chakravarti, D., Sato, T., Jensen, K. B., & Nielsen, O. H. (2024). Organoids as regenerative medicine for inflammatory bowel disease. iScience, 27(6), [110118]. https://doi.org/10.1016/j.isci.2024.110118

Vancouver

Hammerhøj A, Chakravarti D, Sato T, Jensen KB, Nielsen OH. Organoids as regenerative medicine for inflammatory bowel disease. iScience. 2024;27(6). 110118. https://doi.org/10.1016/j.isci.2024.110118

Author

Hammerhøj, Alexander ; Chakravarti, Deepavali ; Sato, Toshiro ; Jensen, Kim Bak ; Nielsen, Ole Haagen. / Organoids as regenerative medicine for inflammatory bowel disease. In: iScience. 2024 ; Vol. 27, No. 6.

Bibtex

@article{8104e8af3df94de18c4a6d640d167802,

title = "Organoids as regenerative medicine for inflammatory bowel disease",

abstract = "Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options. However, the effectiveness of current therapeutics is limited and not universally applicable to all patients and circumstances. Consequently, developing new management strategies is necessary. Recent advances in endoscopically obtained intestinal biopsy specimens have highlighted the potential of intestinal epithelial organoid transplantation as a novel therapeutic approach. Experimental studies using murine and human organoid transplantations have shown promising outcomes, including tissue regeneration and functional recovery. Human trials with organoid therapy have commenced; thus, this article provides readers with insights into the necessity and potential of intestinal organoid transplantation as a new regenerative therapeutic option in clinical settings and explores its associated challenges.",

keywords = "Cell biology, Immunology, Molecular biology, Stem cells research",

author = "Alexander Hammerh{\o}j and Deepavali Chakravarti and Toshiro Sato and Jensen, {Kim Bak} and Nielsen, {Ole Haagen}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

doi = "10.1016/j.isci.2024.110118",

language = "English",

volume = "27",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Organoids as regenerative medicine for inflammatory bowel disease

AU - Hammerhøj, Alexander

AU - Chakravarti, Deepavali

AU - Sato, Toshiro

AU - Jensen, Kim Bak

AU - Nielsen, Ole Haagen

PY - 2024

Y1 - 2024

N2 - Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options. However, the effectiveness of current therapeutics is limited and not universally applicable to all patients and circumstances. Consequently, developing new management strategies is necessary. Recent advances in endoscopically obtained intestinal biopsy specimens have highlighted the potential of intestinal epithelial organoid transplantation as a novel therapeutic approach. Experimental studies using murine and human organoid transplantations have shown promising outcomes, including tissue regeneration and functional recovery. Human trials with organoid therapy have commenced; thus, this article provides readers with insights into the necessity and potential of intestinal organoid transplantation as a new regenerative therapeutic option in clinical settings and explores its associated challenges.

AB - Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options. However, the effectiveness of current therapeutics is limited and not universally applicable to all patients and circumstances. Consequently, developing new management strategies is necessary. Recent advances in endoscopically obtained intestinal biopsy specimens have highlighted the potential of intestinal epithelial organoid transplantation as a novel therapeutic approach. Experimental studies using murine and human organoid transplantations have shown promising outcomes, including tissue regeneration and functional recovery. Human trials with organoid therapy have commenced; thus, this article provides readers with insights into the necessity and potential of intestinal organoid transplantation as a new regenerative therapeutic option in clinical settings and explores its associated challenges.

KW - Cell biology

KW - Immunology

KW - Molecular biology

KW - Stem cells research

U2 - 10.1016/j.isci.2024.110118

DO - 10.1016/j.isci.2024.110118

M3 - Review

C2 - 38947526

AN - SCOPUS:85195104980

VL - 27

JO - iScience

JF - iScience

SN - 2589-0042

IS - 6

M1 - 110118

ER -

ID: 394715935