Optic disc drusen: Dystrophic calcification, a potential target for treatment

Research output: Contribution to journal › Review › Research › peer-review

Standard

Optic disc drusen : Dystrophic calcification, a potential target for treatment. / Bentin, Josephine Mejdahl; Heegaard, Steffen; Jørgensen, Niklas Rye; Grahnemo, Louise; Hamann, Steffen.

In: Eye, Vol. 38, No. 12, 2024, p. 2359-2364.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bentin, JM, Heegaard, S, Jørgensen, NR, Grahnemo, L & Hamann, S 2024, 'Optic disc drusen: Dystrophic calcification, a potential target for treatment', Eye, vol. 38, no. 12, pp. 2359-2364. https://doi.org/10.1038/s41433-024-03138-6

APA

Bentin, J. M., Heegaard, S., Jørgensen, N. R., Grahnemo, L., & Hamann, S. (2024). Optic disc drusen: Dystrophic calcification, a potential target for treatment. Eye, 38(12), 2359-2364. https://doi.org/10.1038/s41433-024-03138-6

Vancouver

Bentin JM, Heegaard S, Jørgensen NR, Grahnemo L, Hamann S. Optic disc drusen: Dystrophic calcification, a potential target for treatment. Eye. 2024;38(12):2359-2364. https://doi.org/10.1038/s41433-024-03138-6

Author

Bentin, Josephine Mejdahl ; Heegaard, Steffen ; Jørgensen, Niklas Rye ; Grahnemo, Louise ; Hamann, Steffen. / Optic disc drusen : Dystrophic calcification, a potential target for treatment. In: Eye. 2024 ; Vol. 38, No. 12. pp. 2359-2364.

Bibtex

@article{745ce69e98ee4bd1acba50284218fc8d,
title = "Optic disc drusen: Dystrophic calcification, a potential target for treatment",
abstract = "Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.",
author = "Bentin, {Josephine Mejdahl} and Steffen Heegaard and J{\o}rgensen, {Niklas Rye} and Louise Grahnemo and Steffen Hamann",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2024.",
year = "2024",
doi = "10.1038/s41433-024-03138-6",
language = "English",
volume = "38",
pages = "2359--2364",
journal = "Eye",
issn = "0950-222X",
publisher = "nature publishing group",
number = "12",

}

RIS

TY - JOUR

T1 - Optic disc drusen

T2 - Dystrophic calcification, a potential target for treatment

AU - Bentin, Josephine Mejdahl

AU - Heegaard, Steffen

AU - Jørgensen, Niklas Rye

AU - Grahnemo, Louise

AU - Hamann, Steffen

N1 - Publisher Copyright: © The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2024.

PY - 2024

Y1 - 2024

N2 - Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.

AB - Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.

U2 - 10.1038/s41433-024-03138-6

DO - 10.1038/s41433-024-03138-6

M3 - Review

C2 - 38778137

AN - SCOPUS:85193817132

VL - 38

SP - 2359

EP - 2364

JO - Eye

JF - Eye

SN - 0950-222X

IS - 12

ER -

ID: 393464285