Normalized cardiopulmonary exercise function in patients with pectus excavatum three years after operation
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: During exercise cardiac function is often limited in patients with pectus excavatum. Therefore, we hypothesized that cardiopulmonary exercise function would improve after the Nuss procedure.
METHODS: Seventy-five teenagers (49 patients, 26 controls) were investigated at rest and during bicycle exercise before surgery, and 1 year and 3 years postoperatively (after pectus-bar removal). Echocardiography and lung spirometry were performed at rest. Cardiac output, heart rate, and aerobic exercise capacity were measured using a photoacoustic gas-rebreathing technique during rest and exercise.
RESULTS: Forty-four patients and 26 controls completed 3 years follow-up. Preoperatively, patients had lower maximum cardiac index, mean ± SD, 6.6 ± 1.2 l·min(-1)·m(-2) compared with controls 8.1 ± 1.0 l·min(-1)·m(-2) during exercise (p = 0.0001). One year and 3 years postoperatively, patients' maximum cardiac index had increased significantly and after 3 years there was no difference between patients and controls (8.1 ± 1.2 l·min(-1)·m(-2) and 8.3 ± 1.6 l·min(-1)·m(-2), respectively [p = 0.572]). The maximum oxygen consumption was unchanged. Left ventricular dimensions increased in patients over 3 years; however, no difference was seen between the 2 groups. Preoperatively, patients had lower forced expiratory volume in the first second of expiration (FEV1; 86% ± 13%) as compared with controls (94% ± 10%), p = 0.009. Postoperatively, no difference was found in FEV1 between the 2 groups.
CONCLUSIONS: Before operation, FEV1 and maximum cardiac index were lower in patients compared with healthy, age-matched controls. One year after, both parameters had increased, although only FEV1 had normalized. After 3 years and bar removal, cardiopulmonary function in patients during exercise had normalized.
Original language | English |
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Journal | The Annals of Thoracic Surgery |
Volume | 96 |
Issue number | 1 |
Pages (from-to) | 272-8 |
Number of pages | 7 |
ISSN | 0003-4975 |
DOIs | |
Publication status | Published - Jul 2013 |
- Adolescent, Exercise/physiology, Exercise Test/methods, Female, Follow-Up Studies, Funnel Chest/diagnosis, Humans, Lung/physiology, Magnetic Resonance Imaging, Male, Postoperative Period, Prospective Studies, Recovery of Function, Respiratory Function Tests/methods, Surveys and Questionnaires, Thoracoplasty, Time Factors, Treatment Outcome
Research areas
ID: 242613089