No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial
Research output: Contribution to journal › Journal article › Research › peer-review
A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemia-reperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress.
Original language | English |
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Journal | European Journal of Vascular and Endovascular Surgery |
Volume | 40 |
Issue number | 4 |
Pages (from-to) | 461-7 |
Number of pages | 7 |
ISSN | 1078-5884 |
DOIs | |
Publication status | Published - 1 Oct 2010 |
ID: 34073024