New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors
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New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. / Liebscher, Ines; Ackley, Brian; Araç, Demet; Ariestanti, Donna M; Aust, Gabriela; Bae, Byoung-il; Bista, Bigyan R; Bridges, James P; Duman, Joseph G; Engel, Felix B; Giera, Stefanie; Goffinet, André M; Hall, Randy A; Hamann, Jörg; Hartmann, Nicole; Lin, Hsi-Hsien; Liu, Mingyao; Luo, Rong; Mogha, Amit; Monk, Kelly R; Cornelia Peeters, Miriam; Prömel, Simone; Ressl, Susanne; Schiöth, Helgi B; Sigoillot, Séverine M; Song, Helen; Talbot, William S; Tall, Gregory G; White, James P; Wolfrum, Uwe; Xu, Lei; Piao, Xianhua.
In: Annals of the New York Academy of Sciences, Vol. 1333, 12.2014, p. 43-64.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors
AU - Liebscher, Ines
AU - Ackley, Brian
AU - Araç, Demet
AU - Ariestanti, Donna M
AU - Aust, Gabriela
AU - Bae, Byoung-il
AU - Bista, Bigyan R
AU - Bridges, James P
AU - Duman, Joseph G
AU - Engel, Felix B
AU - Giera, Stefanie
AU - Goffinet, André M
AU - Hall, Randy A
AU - Hamann, Jörg
AU - Hartmann, Nicole
AU - Lin, Hsi-Hsien
AU - Liu, Mingyao
AU - Luo, Rong
AU - Mogha, Amit
AU - Monk, Kelly R
AU - Cornelia Peeters, Miriam
AU - Prömel, Simone
AU - Ressl, Susanne
AU - Schiöth, Helgi B
AU - Sigoillot, Séverine M
AU - Song, Helen
AU - Talbot, William S
AU - Tall, Gregory G
AU - White, James P
AU - Wolfrum, Uwe
AU - Xu, Lei
AU - Piao, Xianhua
N1 - © 2014 New York Academy of Sciences.
PY - 2014/12
Y1 - 2014/12
N2 - The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain-mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. We discuss recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs.
AB - The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain-mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. We discuss recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs.
KW - Animals
KW - Cell Adhesion
KW - Developmental Disabilities
KW - Humans
KW - Mutation
KW - Neoplasms
KW - Receptors, G-Protein-Coupled
KW - Signal Transduction
KW - Synapses
U2 - 10.1111/nyas.12580
DO - 10.1111/nyas.12580
M3 - Journal article
C2 - 25424900
VL - 1333
SP - 43
EP - 64
JO - Annals of The Lyceum of Natural History of New York
JF - Annals of The Lyceum of Natural History of New York
SN - 0077-8923
ER -
ID: 135484069