Neuromuscular blockade during laparoscopic ventral herniotomy: protocol for a randomised controlled trial
Research output: Contribution to journal › Journal article › Research › peer-review
INTRODUCTION: Laparoscopic herniotomy is the preferred technique for some ventral hernias. Several factors may influence the surgical conditions, one being the depth of neuromuscular blockade (NMB) applied. We hypothesised that deep neuromuscular blockade defined as a post-tetanic count below eight would provide a better surgical workspace.
METHODS: This was an investigator-initiated, assessor- and patient-blinded randomised cross-over study. A total of 34 patients with planned laparoscopic umbilical, incisional and linea alba herniotomy were studied. Patients would be randomised to receive deep NMB followed by no NMB, or no NMB followed by deep NMB. Our primary outcome was improvement of the surgical workspace (rated on a five-point scale) estimated as the difference between the workspace during deep NMB and the workspace without NMB. Secondary outcomes included, among others, surgeon's rating of surgical conditions during suturing, duration of surgery and duration of the suturing of the hernia.
CONCLUSION: This randomised cross-over study investigated a potential effect on the surgical workspace in laparoscopic ventral herniotomy using deep NMB compared with no NMB. The study may provide knowledge relevant to other laparoscopic techniques.
FUNDING: The study is funded by a research grant from the Investigator Initiated Studies Program of Merck Sharp & Dohme Corp.
TRIAL REGISTRATION: NCT02247466.
Original language | English |
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Article number | A5120 |
Journal | Danish Medical Journal |
Volume | 62 |
Issue number | 8 |
Pages (from-to) | 1-6 |
Number of pages | 6 |
ISSN | 2245-1919 |
Publication status | Published - Aug 2015 |
- Adult, Clinical Protocols, Cross-Over Studies, Double-Blind Method, Hernia, Ventral, Herniorrhaphy, Humans, Intraoperative Period, Laparoscopy, Monitoring, Intraoperative, Neuromuscular Blockade, Operative Time, Suture Techniques, Treatment Outcome
Research areas
Links
- http://www.danmedj.dk/portal/pls/portal/!PORTAL.wwpob_page.show?_docname=10969424.PDF
Final published version
ID: 161585241