Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients
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Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients. / Nordholm, Dorte; Rostrup, Egill; Mondelli, Valeria; Randers, Lasse; Nielsen, Mette Ø; Wulff, Sanne; Nørbak-Emig, Henrik; Broberg, Brian V; Krakauer, Kristine; Dazzan, Paola; Zunszain, Patricia A; Nordentoft, Merete; Glenthøj, Birte.
In: Psychoneuroendocrinology, Vol. 92, 2018, p. 72-80.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients
AU - Nordholm, Dorte
AU - Rostrup, Egill
AU - Mondelli, Valeria
AU - Randers, Lasse
AU - Nielsen, Mette Ø
AU - Wulff, Sanne
AU - Nørbak-Emig, Henrik
AU - Broberg, Brian V
AU - Krakauer, Kristine
AU - Dazzan, Paola
AU - Zunszain, Patricia A
AU - Nordentoft, Merete
AU - Glenthøj, Birte
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: Abnormalities within hypothalamus-pituitary-adrenal (HPA) axis might interact with other neurobiological systems to enhance the risk of psychosis. Most of the neurodevelopmental and HPA axis changes occur in adolescence; this is also the period when prodromal and psychotic symptoms occur for the first time. More knowledge about how various stress components interact can advance understanding of the link between psychosis and the HPA axis.METHOD: We examined 41 ultra high-risk (UHR) patients and 40 antipsychotic-naïve first-episode schizophrenia (FES) patients and compared them with 47 matched controls. The Perceived Stress Scale and the Recent Life Events Questionnaire were used to assess the stress levels. Day-time saliva samples were taken to measure cortisol. The pituitary gland volume was measured manually on the structural MRI using stereology.RESULTS: Only the UHR patients, had a higher cortisol increase just after awakening (p = 0.009) compared to healthy controls. In UHR patients, we found a negative correlation between cortisol increase after awakening and symptom severity (p = 0.008). Pituitary gland volume and diurnal cortisol were not significantly different among the three groups. There was no correlation between pituitary gland volume, perceived stress/recent life events and any of the cortisol measures or symptoms.CONCLUSION: Symptom severity during the very early phase of illness (UHR) seems to be associated with altered cortisol increase. Longitudinal studies in UHR patients would be useful to examine how stress levels affect the course of the illness.
AB - INTRODUCTION: Abnormalities within hypothalamus-pituitary-adrenal (HPA) axis might interact with other neurobiological systems to enhance the risk of psychosis. Most of the neurodevelopmental and HPA axis changes occur in adolescence; this is also the period when prodromal and psychotic symptoms occur for the first time. More knowledge about how various stress components interact can advance understanding of the link between psychosis and the HPA axis.METHOD: We examined 41 ultra high-risk (UHR) patients and 40 antipsychotic-naïve first-episode schizophrenia (FES) patients and compared them with 47 matched controls. The Perceived Stress Scale and the Recent Life Events Questionnaire were used to assess the stress levels. Day-time saliva samples were taken to measure cortisol. The pituitary gland volume was measured manually on the structural MRI using stereology.RESULTS: Only the UHR patients, had a higher cortisol increase just after awakening (p = 0.009) compared to healthy controls. In UHR patients, we found a negative correlation between cortisol increase after awakening and symptom severity (p = 0.008). Pituitary gland volume and diurnal cortisol were not significantly different among the three groups. There was no correlation between pituitary gland volume, perceived stress/recent life events and any of the cortisol measures or symptoms.CONCLUSION: Symptom severity during the very early phase of illness (UHR) seems to be associated with altered cortisol increase. Longitudinal studies in UHR patients would be useful to examine how stress levels affect the course of the illness.
U2 - 10.1016/j.psyneuen.2018.03.015
DO - 10.1016/j.psyneuen.2018.03.015
M3 - Journal article
C2 - 29635174
VL - 92
SP - 72
EP - 80
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -
ID: 213039797