Molecular Typing of Treponema pallidum in Denmark: A Nationwide Study of Syphilis
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The aim of this nationwide study is to determine the strain type diversity among patients diagnosed with syphilis by PCR during a 4-year period in Denmark. Epidemiological data, including HIV status, for all patients were obtained from the Danish national syphilis registration system. Molecular strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93%) of the patients reported acquiring syphilis in Denmark. Among patients with concurrent HIV, 9 full strain types were identified and no difference in strain type was found by HIV status (p = 0.197). In conclusion, the majority of patients were infected in Denmark and the HIV-infected syphilis patients were diagnosed with a wide spectrum of different strain types of Treponema pallidum.
Original language | English |
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Journal | Acta Dermatovenereologica |
Volume | 96 |
Pages (from-to) | 202-206 |
Number of pages | 5 |
ISSN | 0001-5555 |
DOIs | |
Publication status | Published - 2016 |
ID: 161420321