Molecular markers for tolerance of European ash (Fraxinus excelsior) to dieback disease identified using Associative Transcriptomics
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Molecular markers for tolerance of European ash (Fraxinus excelsior) to dieback disease identified using Associative Transcriptomics. / Harper, Andrea L.; McKinney, Lea Vig; Nielsen, Lene Rostgaard; Havlickova, Lenka; Li, Yi; Trick, Martin; Fraser, Fiona; Wang, Lihong; Fellgett, Alison; Sollars, Elizabeth S A; Janacek, Sophie H.; Downie, J. Allan; Buggs, Richard J A; Kjær, Erik Dahl; Bancroft, Ian.
In: Scientific Reports, Vol. 6, 19335, 13.01.2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molecular markers for tolerance of European ash (Fraxinus excelsior) to dieback disease identified using Associative Transcriptomics
AU - Harper, Andrea L.
AU - McKinney, Lea Vig
AU - Nielsen, Lene Rostgaard
AU - Havlickova, Lenka
AU - Li, Yi
AU - Trick, Martin
AU - Fraser, Fiona
AU - Wang, Lihong
AU - Fellgett, Alison
AU - Sollars, Elizabeth S A
AU - Janacek, Sophie H.
AU - Downie, J. Allan
AU - Buggs, Richard J A
AU - Kjær, Erik Dahl
AU - Bancroft, Ian
PY - 2016/1/13
Y1 - 2016/1/13
N2 - Tree disease epidemics are a global problem, impacting food security, biodiversity and national economies. The potential for conservation and breeding in trees is hampered by complex genomes and long lifecycles, with most species lacking genomic resources. The European Ash tree Fraxinus excelsior is being devastated by the fungal pathogen Hymenoscyphus fraxineus, which causes ash dieback disease. Taking this system as an example and utilizing Associative Transcriptomics for the first time in a plant pathology study, we discovered gene sequence and gene expression variants across a genetic diversity panel scored for disease symptoms and identified markers strongly associated with canopy damage in infected trees. Using these markers we predicted phenotypes in a test panel of unrelated trees, successfully identifying individuals with a low level of susceptibility to the disease. Co-expression analysis suggested that pre-priming of defence responses may underlie reduced susceptibility to ash dieback.
AB - Tree disease epidemics are a global problem, impacting food security, biodiversity and national economies. The potential for conservation and breeding in trees is hampered by complex genomes and long lifecycles, with most species lacking genomic resources. The European Ash tree Fraxinus excelsior is being devastated by the fungal pathogen Hymenoscyphus fraxineus, which causes ash dieback disease. Taking this system as an example and utilizing Associative Transcriptomics for the first time in a plant pathology study, we discovered gene sequence and gene expression variants across a genetic diversity panel scored for disease symptoms and identified markers strongly associated with canopy damage in infected trees. Using these markers we predicted phenotypes in a test panel of unrelated trees, successfully identifying individuals with a low level of susceptibility to the disease. Co-expression analysis suggested that pre-priming of defence responses may underlie reduced susceptibility to ash dieback.
UR - http://www.scopus.com/inward/record.url?scp=84954128405&partnerID=8YFLogxK
U2 - 10.1038/srep19335
DO - 10.1038/srep19335
M3 - Journal article
C2 - 26757823
AN - SCOPUS:84954128405
VL - 6
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 19335
ER -
ID: 154412352