Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations

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Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations. / Søe, Rikke; Andreasen, Mogens; Klærke, Dan Arne.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1788, No. 9, 2009, p. 1706-1713.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Søe, R, Andreasen, M & Klærke, DA 2009, 'Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations', Biochimica et Biophysica Acta - Biomembranes, vol. 1788, no. 9, pp. 1706-1713. https://doi.org/10.1016/j.bbamem.2009.07.002

APA

Søe, R., Andreasen, M., & Klærke, D. A. (2009). Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations. Biochimica et Biophysica Acta - Biomembranes, 1788(9), 1706-1713. https://doi.org/10.1016/j.bbamem.2009.07.002

Vancouver

Søe R, Andreasen M, Klærke DA. Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations. Biochimica et Biophysica Acta - Biomembranes. 2009;1788(9):1706-1713. https://doi.org/10.1016/j.bbamem.2009.07.002

Author

Søe, Rikke ; Andreasen, Mogens ; Klærke, Dan Arne. / Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations. In: Biochimica et Biophysica Acta - Biomembranes. 2009 ; Vol. 1788, No. 9. pp. 1706-1713.

Bibtex

@article{4716c7c0a83211debc73000ea68e967b,
title = "Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations",
abstract = "This work demonstrates that extracellular Na(+) modulates the cloned inwardly rectifying K(+) channels Kir4.1 and Kir4.1-Kir5.1. Whole-cell patch clamp studies on astrocytes have previously indicated that inward potassium currents are regulated by external Na(+). We expressed Kir4.1 and Kir4.1-Kir5.1 in Xenopus oocytes to disclose if Kir4.1 and/or Kir4.1-Kir5.1 at the molecular level are responsible for the observed effect of [Na(+)](o) and to investigate the regulatory mechanism of external cations further. Our results showed that Na(+) has a biphasic modulatory effect on both Kir4.1 and Kir4.1-Kir5.1 currents. Depending on the Na(+)-concentration and applied voltage, the inward Kir4.1/Kir4.1-Kir5.1 currents are either enhanced or reduced by extracellular Na(+). The Na(+) activation was voltage-independent, whereas the Na(+)-induced reduction of the Kir4.1 and Kir4.1-Kir5.1 currents was both concentration-, time- and voltage-dependent. Our data indicate that the biphasic effect of extracellular Na(+)on the Kir4.1 and Kir4.1-Kir5.1 channels is caused by two separate mechanisms.",
author = "Rikke S{\o}e and Mogens Andreasen and Kl{\ae}rke, {Dan Arne}",
year = "2009",
doi = "10.1016/j.bbamem.2009.07.002",
language = "English",
volume = "1788",
pages = "1706--1713",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations

AU - Søe, Rikke

AU - Andreasen, Mogens

AU - Klærke, Dan Arne

PY - 2009

Y1 - 2009

N2 - This work demonstrates that extracellular Na(+) modulates the cloned inwardly rectifying K(+) channels Kir4.1 and Kir4.1-Kir5.1. Whole-cell patch clamp studies on astrocytes have previously indicated that inward potassium currents are regulated by external Na(+). We expressed Kir4.1 and Kir4.1-Kir5.1 in Xenopus oocytes to disclose if Kir4.1 and/or Kir4.1-Kir5.1 at the molecular level are responsible for the observed effect of [Na(+)](o) and to investigate the regulatory mechanism of external cations further. Our results showed that Na(+) has a biphasic modulatory effect on both Kir4.1 and Kir4.1-Kir5.1 currents. Depending on the Na(+)-concentration and applied voltage, the inward Kir4.1/Kir4.1-Kir5.1 currents are either enhanced or reduced by extracellular Na(+). The Na(+) activation was voltage-independent, whereas the Na(+)-induced reduction of the Kir4.1 and Kir4.1-Kir5.1 currents was both concentration-, time- and voltage-dependent. Our data indicate that the biphasic effect of extracellular Na(+)on the Kir4.1 and Kir4.1-Kir5.1 channels is caused by two separate mechanisms.

AB - This work demonstrates that extracellular Na(+) modulates the cloned inwardly rectifying K(+) channels Kir4.1 and Kir4.1-Kir5.1. Whole-cell patch clamp studies on astrocytes have previously indicated that inward potassium currents are regulated by external Na(+). We expressed Kir4.1 and Kir4.1-Kir5.1 in Xenopus oocytes to disclose if Kir4.1 and/or Kir4.1-Kir5.1 at the molecular level are responsible for the observed effect of [Na(+)](o) and to investigate the regulatory mechanism of external cations further. Our results showed that Na(+) has a biphasic modulatory effect on both Kir4.1 and Kir4.1-Kir5.1 currents. Depending on the Na(+)-concentration and applied voltage, the inward Kir4.1/Kir4.1-Kir5.1 currents are either enhanced or reduced by extracellular Na(+). The Na(+) activation was voltage-independent, whereas the Na(+)-induced reduction of the Kir4.1 and Kir4.1-Kir5.1 currents was both concentration-, time- and voltage-dependent. Our data indicate that the biphasic effect of extracellular Na(+)on the Kir4.1 and Kir4.1-Kir5.1 channels is caused by two separate mechanisms.

U2 - 10.1016/j.bbamem.2009.07.002

DO - 10.1016/j.bbamem.2009.07.002

M3 - Journal article

C2 - 19616510

VL - 1788

SP - 1706

EP - 1713

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 9

ER -

ID: 14640424