Modular design principle based on compartmental drug delivery systems q
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Modular design principle based on compartmental drug delivery systems q. / Eleftheriadis, Georgios K.; Genina, Natalja; Boetker, Johan; Rantanen, Jukka.
In: Advanced Drug Delivery Reviews, Vol. 178, 113921, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Modular design principle based on compartmental drug delivery systems q
AU - Eleftheriadis, Georgios K.
AU - Genina, Natalja
AU - Boetker, Johan
AU - Rantanen, Jukka
PY - 2021
Y1 - 2021
N2 - The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release. (c) 2021 Published by Elsevier B.V.
AB - The current manufacturing solutions for oral solid dosage forms are fundamentally based on technologies from the 19th century. This approach is well suited for mass production of one-size-fits-all products; however, it does not allow for a straight-forward personalization and mass customization of the pharmaceutical end-product. In order to provide better therapies to the patients, a need for innovative manufacturing concepts and product design principles has been rising. Additive manufacturing opens up a possibility for compartmentalization of drug products, including design of spatially separated multidrug and functional excipient compartments. This compartmentalized solution can be further expanded to modular design thinking. Modular design is referring to combination of building blocks containing a given amount of drug compound(s) and related functional excipients into a larger final product. Implementation of modular design principles is paving the way for implementing the emerging personalization potential within health sciences by designing compartmental and reactive product structures that can be manufactured based on the individual needs of each patient. This review will introduce the existing compartmentalized product design principles and discuss the integration of these into edible electronics allowing for innovative control of drug release. (c) 2021 Published by Elsevier B.V.
KW - Additive manufacturing
KW - 3D printing
KW - Compartmental systems
KW - Modular systems
KW - Drug delivery
KW - Smart medications
KW - Ingestible electronics
KW - Digital reconstruction
KW - Intellectual property
KW - ORODISPERSIBLE FILMS
KW - PRINTED PHARMACEUTICALS
KW - COMBINATION THERAPY
KW - INNOVATIVE APPROACH
KW - ORAL DELIVERY
KW - DOSAGE FORMS
KW - RELEASE
KW - TABLETS
KW - EXTRUSION
KW - ACCEPTABILITY
U2 - 10.1016/j.addr.2021.113921
DO - 10.1016/j.addr.2021.113921
M3 - Review
C2 - 34390776
VL - 178
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
M1 - 113921
ER -
ID: 288273527