Methods of Assessing Human Tendon Metabolism and Tissue Properties in Response to Changes in Mechanical Loading
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Methods of Assessing Human Tendon Metabolism and Tissue Properties in Response to Changes in Mechanical Loading. / Heinemeier, Katja M; Kjaer, Michael; Magnusson, S Peter.
Metabolic Influences on Risk for Tendon Disorders: Pary 1. Vol. 920 Springer, 2016. p. 97-106 (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Methods of Assessing Human Tendon Metabolism and Tissue Properties in Response to Changes in Mechanical Loading
AU - Heinemeier, Katja M
AU - Kjaer, Michael
AU - Magnusson, S Peter
PY - 2016
Y1 - 2016
N2 - In recent years a number of methodological developments have improved the opportunities to study human tendon. Microdialysis enables sampling of interstitial fluid in the peritendon tissue, while sampling of human tendon biopsies allows direct analysis of tendon tissue for gene- and protein expression as well as protein synthesis rate. Further the (14)C bomb-pulse method has provided data on long-term tissue turnover in human tendon. Non-invasive techniques allow measurement of tendon metabolism (positron emission tomography (PET)), tendon morphology (magnetic resonance imaging (MRI)), and tendon mechanical properties (ultrasonography combined with force measurement during movement). Finally, 3D cell cultures of human tendon cells provide the opportunity to investigate cell-matrix interactions in response to various interventions.
AB - In recent years a number of methodological developments have improved the opportunities to study human tendon. Microdialysis enables sampling of interstitial fluid in the peritendon tissue, while sampling of human tendon biopsies allows direct analysis of tendon tissue for gene- and protein expression as well as protein synthesis rate. Further the (14)C bomb-pulse method has provided data on long-term tissue turnover in human tendon. Non-invasive techniques allow measurement of tendon metabolism (positron emission tomography (PET)), tendon morphology (magnetic resonance imaging (MRI)), and tendon mechanical properties (ultrasonography combined with force measurement during movement). Finally, 3D cell cultures of human tendon cells provide the opportunity to investigate cell-matrix interactions in response to various interventions.
KW - Journal Article
U2 - 10.1007/978-3-319-33943-6_8
DO - 10.1007/978-3-319-33943-6_8
M3 - Book chapter
C2 - 27535251
SN - 978-3-319-33941-2
VL - 920
T3 - Advances in Experimental Medicine and Biology
SP - 97
EP - 106
BT - Metabolic Influences on Risk for Tendon Disorders
PB - Springer
ER -
ID: 178578220