Maternal and cord blood 25-hydroxyvitamin D3 are associated with increased cord blood and naive and activated regulatory T cells: The Barwon infant study
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Maternal and cord blood 25-hydroxyvitamin D3 are associated with increased cord blood and naive and activated regulatory T cells : The Barwon infant study. / Barwon Infant Study Investigator Group.
In: Journal of Immunology, Vol. 206, No. 4, 2021, p. 874-882.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal and cord blood 25-hydroxyvitamin D3 are associated with increased cord blood and naive and activated regulatory T cells
T2 - The Barwon infant study
AU - Thorsen, Steffen U.
AU - Collier, Fiona
AU - Pezic, Angela
AU - O’Hely, Martin
AU - Clarke, Michael
AU - Tang, Mimi
AU - Burgner, David
AU - Vuillermin, Peter
AU - Ponsonby, Anne Louise
AU - Carlin, John
AU - Tang, Mimi
AU - Collier, Fiona
AU - Dwyer, Terry
AU - Ranganathan, Sarath
AU - Sly, Peter
AU - Harrison, Len
AU - Burgner, David
AU - Barwon Infant Study Investigator Group
N1 - Publisher Copyright: Copyright © 2021 by The American Association of Immunologists, Inc.
PY - 2021
Y1 - 2021
N2 - Vitamin D has shown immune-modulatory effects but mostly in in vitro and animal studies. Regulatory T cells (Treg) are important for a balanced immune system. The relationship between vitamin D on the number of circulating neonatal Treg is unclear. We sought to investigate the association between maternal and neonatal vitamin D metabolites and cord blood (CB) Treg subsets. In a cohort of Australian infants (n = 1074), recruited using an unselected antenatal sampling frame, 158 mother–infant pairs had data on the following: 1) 25-hydroxyvitamin D3 (25(OH)D3) measures in both maternal peripheral blood (28- to 32-wk gestation) and infant CB; 2) proportions (percentage of CD4+ T cells) of CB Treg subsets (CD4+CD45RA+ FOXP3low naive Treg, and CD4+CD45RA2 FOXP3high activated Treg [aTreg]); and 3) possible confounders, including maternal personal UV radiation. Multiple regression analyses were used. The median 25(OH)D3 was 85.4 and 50.7 nmol/l for maternal and CB samples, respectively. Higher maternal 25(OH)D3 levels were associated with increased CB naive Treg (relative adjusted mean difference [AMD] per 25 nmol/l increase: 5%; 95% confidence interval [CI]: 1–9%), and aTreg (AMD per 25 nmol/l increase: 17%; 95% CI: 6–28%). Furthermore, a positive association between CB 25(OH)D3 levels and CB aTreg (AMD per 25 nmol/l increase: 29%; 95% CI: 13–48%) was also evident. These results persisted after adjustment for other factors such as maternal personal UV radiation and season of birth. 25(OH)D3, may play a role in the adaptive neonatal immune system via induction of FOXP3+ Tregs. Further studies of immune priming actions of antenatal 25(OH)D3 are warranted.
AB - Vitamin D has shown immune-modulatory effects but mostly in in vitro and animal studies. Regulatory T cells (Treg) are important for a balanced immune system. The relationship between vitamin D on the number of circulating neonatal Treg is unclear. We sought to investigate the association between maternal and neonatal vitamin D metabolites and cord blood (CB) Treg subsets. In a cohort of Australian infants (n = 1074), recruited using an unselected antenatal sampling frame, 158 mother–infant pairs had data on the following: 1) 25-hydroxyvitamin D3 (25(OH)D3) measures in both maternal peripheral blood (28- to 32-wk gestation) and infant CB; 2) proportions (percentage of CD4+ T cells) of CB Treg subsets (CD4+CD45RA+ FOXP3low naive Treg, and CD4+CD45RA2 FOXP3high activated Treg [aTreg]); and 3) possible confounders, including maternal personal UV radiation. Multiple regression analyses were used. The median 25(OH)D3 was 85.4 and 50.7 nmol/l for maternal and CB samples, respectively. Higher maternal 25(OH)D3 levels were associated with increased CB naive Treg (relative adjusted mean difference [AMD] per 25 nmol/l increase: 5%; 95% confidence interval [CI]: 1–9%), and aTreg (AMD per 25 nmol/l increase: 17%; 95% CI: 6–28%). Furthermore, a positive association between CB 25(OH)D3 levels and CB aTreg (AMD per 25 nmol/l increase: 29%; 95% CI: 13–48%) was also evident. These results persisted after adjustment for other factors such as maternal personal UV radiation and season of birth. 25(OH)D3, may play a role in the adaptive neonatal immune system via induction of FOXP3+ Tregs. Further studies of immune priming actions of antenatal 25(OH)D3 are warranted.
U2 - 10.4049/jimmunol.2000515
DO - 10.4049/jimmunol.2000515
M3 - Journal article
C2 - 33431661
AN - SCOPUS:85100470401
VL - 206
SP - 874
EP - 882
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -
ID: 279687732