Long-Term Risk of Hospitalization for Somatic Diseases among Survivors of Childhood Acute Lymphoblastic Leukemia
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Long-Term Risk of Hospitalization for Somatic Diseases among Survivors of Childhood Acute Lymphoblastic Leukemia. / Sørensen, Gitte Vrelits; Albieri, Vanna; Holmqvist, Anna Sällfors; Erdmann, Friederike; Mogensen, Hanna; Talbäck, Mats; Ifversen, Marianne; Lash, Timothy Lee; Feychting, Maria; Schmiegelow, Kjeld; Heyman, Mats Marshall; Winther, Jeanette Falck; Hasle, Henrik.
In: JNCI Cancer Spectrum, Vol. 6, No. 2, pkac029, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-Term Risk of Hospitalization for Somatic Diseases among Survivors of Childhood Acute Lymphoblastic Leukemia
AU - Sørensen, Gitte Vrelits
AU - Albieri, Vanna
AU - Holmqvist, Anna Sällfors
AU - Erdmann, Friederike
AU - Mogensen, Hanna
AU - Talbäck, Mats
AU - Ifversen, Marianne
AU - Lash, Timothy Lee
AU - Feychting, Maria
AU - Schmiegelow, Kjeld
AU - Heyman, Mats Marshall
AU - Winther, Jeanette Falck
AU - Hasle, Henrik
N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press.
PY - 2022
Y1 - 2022
N2 - Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed with ALL before age 20 years in 1982-2008 were identified in the national cancer registries. Five-year survivors and matched population comparisons without childhood cancer were followed for hospitalization for 120 somatic disease categories in the national hospital registries from 5 years postdiagnosis until 2017, and disease-specific hospitalization rate ratios (RR) were calculated. The mean cumulative count method was used to estimate the mean number of multiple and recurrent disease-specific hospitalizations per individual. Results: A total of 2024 5-year survivors and 9797 population comparisons were included. The overall hospitalization rate was more than twice as high compared with comparisons (RR = 2.30, 95% confidence interval [CI] = 2.09 to 2.52). At 30 years postdiagnosis, the mean cumulative hospitalization count was 1.69 (95% CI = 1.47 to 1.90) per survivor and 0.80 (95% CI = 0.73 to 0.86) per comparison. In the subcohort without relapse or HSCT (n = 1709), the RR was 1.41 (95% CI = 1.27 to 1.58). Conclusions: Survivors of childhood ALL were at increased long-term risk for disease-specific hospitalizations; however, in survivors without relapse or HSCT, the rate was only modestly higher than in population comparisons without a childhood cancer. The absolute mean numbers of multiple and recurrent hospitalizations were generally low.
AB - Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed with ALL before age 20 years in 1982-2008 were identified in the national cancer registries. Five-year survivors and matched population comparisons without childhood cancer were followed for hospitalization for 120 somatic disease categories in the national hospital registries from 5 years postdiagnosis until 2017, and disease-specific hospitalization rate ratios (RR) were calculated. The mean cumulative count method was used to estimate the mean number of multiple and recurrent disease-specific hospitalizations per individual. Results: A total of 2024 5-year survivors and 9797 population comparisons were included. The overall hospitalization rate was more than twice as high compared with comparisons (RR = 2.30, 95% confidence interval [CI] = 2.09 to 2.52). At 30 years postdiagnosis, the mean cumulative hospitalization count was 1.69 (95% CI = 1.47 to 1.90) per survivor and 0.80 (95% CI = 0.73 to 0.86) per comparison. In the subcohort without relapse or HSCT (n = 1709), the RR was 1.41 (95% CI = 1.27 to 1.58). Conclusions: Survivors of childhood ALL were at increased long-term risk for disease-specific hospitalizations; however, in survivors without relapse or HSCT, the rate was only modestly higher than in population comparisons without a childhood cancer. The absolute mean numbers of multiple and recurrent hospitalizations were generally low.
U2 - 10.1093/jncics/pkac029
DO - 10.1093/jncics/pkac029
M3 - Journal article
C2 - 35603856
AN - SCOPUS:85136910639
VL - 6
JO - JNCI Cancer Spectrum
JF - JNCI Cancer Spectrum
SN - 2515-5091
IS - 2
M1 - pkac029
ER -
ID: 324599450