Long-term mortality in patients with atrial septal defect: a nationwide cohort-study
Research output: Contribution to journal › Journal article › Research › peer-review
Aims: In this nationwide cohort of atrial septal defect (ASD) patients, the largest to date, we report the longest follow-up time with and without closure in childhood and adulthood compared with a general population cohort.
Methods and results: Using population-based registries, we included Danish individuals born before 1994 who received an ASD diagnosis between 1959 and 2013. All diagnoses were subsequently validated (n = 2277). Using the Kaplan-Meier estimates and Cox proportional hazards regression adjusted for sex, birth year, and a modified Charlson Comorbidity Index, we compared the mortality of ASD patients with that of a birth year and sex matched general population cohort. The median follow-up from ASD diagnosis was 18.1 years (range 1-53 years). Patients with ASD had a higher mortality [adjusted hazard ratio (HR): 1.7; 95% confidence interval (CI): 1.5-1.9] compared with the general population cohort. The adjusted HR 30 days after closure was 1.4 (95% CI: 1.2-1.7), and it was 2.4 (95% CI: 2.0-2.9) for patients without closure.
Conclusion: Overall, ASD patients had a higher long-term mortality than a general population cohort matched on birth year and gender. Our data indicate a lower relative mortality of those ASD patients undergoing closure than the ASD patients not undergoing closure.
Original language | English |
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Journal | European Heart Journal |
Volume | 39 |
Issue number | 12 |
Pages (from-to) | 993-998 |
Number of pages | 6 |
ISSN | 0195-668X |
DOIs | |
Publication status | Published - 2018 |
Externally published | Yes |
- Adolescent, Adult, Cardiac Catheterization/methods, Child, Child, Preschool, Denmark/epidemiology, Female, Follow-Up Studies, Forecasting, Heart Septal Defects, Atrial/diagnosis, Humans, Infant, Male, Middle Aged, Population Surveillance, Registries, Retrospective Studies, Risk Factors, Survival Rate/trends, Young Adult
Research areas
ID: 241757931